WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463211
Description: E 3040 is a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase. It is involved with eicosanoid production. E 3040 also has anti-inflammatory properties.
MedKoo Cat#: 463211
Name: E 3040
Chemical Formula: C16H17N3OS
Exact Mass: 299.1092
Molecular Weight: 299.392
Elemental Analysis: C, 64.19; H, 5.72; N, 14.04; O, 5.34; S, 10.71
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: E 3040; E3040; E-3040;
IUPAC/Chemical Name: 5,7-dimethyl-2-(methylamino)-4-(pyridin-3-ylmethyl)benzo[d]thiazol-6-ol
InChi Key: IONAQTGMWFXHIX-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H17N3OS/c1-9-12(7-11-5-4-6-18-8-11)13-15(10(2)14(9)20)21-16(17-3)19-13/h4-6,8,20H,7H2,1-3H3,(H,17,19)
SMILES Code: CNc(n1)sc2c1c(Cc3cnccc3)c(C)c(O)c2C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 299.392 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Oketani K, Nagakura N, Harada K, Inoue T. In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production. Eur J Pharmacol. 2001 Jun 22;422(1-3):209-16. doi: 10.1016/s0014-2999(01)01022-6. PMID: 11430933.
2: Yamada H, Kotaki H, Furitsu H, Sawada Y, Iga T. Mechanism of the uricosuric action of the anti-inflammatory drug E3040 used to treat inflammatory bowel disease I: study using a rat model of hyperuricemia. Biopharm Drug Dispos. 1999 Mar;20(2):77-83. doi: 10.1002/(sici)1099-081x(199903)20:2<77::aid- bdd154>3.0.co;2-d. PMID: 10206322.