E 3040

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463211

CAS#: 145096-30-6

Description: E 3040 is a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase. It is involved with eicosanoid production. E 3040 also has anti-inflammatory properties.

Chemical Structure

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E 3040
CAS# 145096-30-6
Instruction

Theoretical Analysis

MedKoo Cat#: 463211
Name: E 3040
CAS#: 145096-30-6
Chemical Formula: C16H17N3OS
Exact Mass: 299.1092
Molecular Weight: 299.392
Elemental Analysis: C, 64.19; H, 5.72; N, 14.04; O, 5.34; S, 10.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: E 3040; E3040; E-3040;

IUPAC/Chemical Name: 5,7-dimethyl-2-(methylamino)-4-(pyridin-3-ylmethyl)benzo[d]thiazol-6-ol

InChi Key: IONAQTGMWFXHIX-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17N3OS/c1-9-12(7-11-5-4-6-18-8-11)13-15(10(2)14(9)20)21-16(17-3)19-13/h4-6,8,20H,7H2,1-3H3,(H,17,19)

SMILES Code: CNc(n1)sc2c1c(Cc3cnccc3)c(C)c(O)c2C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 299.392 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Oketani K, Nagakura N, Harada K, Inoue T. In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production. Eur J Pharmacol. 2001 Jun 22;422(1-3):209-16. doi: 10.1016/s0014-2999(01)01022-6. PMID: 11430933.

2: Yamada H, Kotaki H, Furitsu H, Sawada Y, Iga T. Mechanism of the uricosuric action of the anti-inflammatory drug E3040 used to treat inflammatory bowel disease I: study using a rat model of hyperuricemia. Biopharm Drug Dispos. 1999 Mar;20(2):77-83. doi: 10.1002/(sici)1099-081x(199903)20:2<77::aid- bdd154>3.0.co;2-d. PMID: 10206322.

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E 3040