WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574947
Description: ZM-449829 is an inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site and inhibits STAT-5 phosphorylation and T cell proliferation.
MedKoo Cat#: 574947
Chemical Formula: C13H10O
Exact Mass: 182.0732
Molecular Weight: 182.22
Elemental Analysis: C, 85.69; H, 5.53; O, 8.78
Synonym: ZM-449829; ZM 449829; ZM449829
IUPAC/Chemical Name: 1-(2-Naphthalenyl)-2-propen-1-one
InChi Key: FOTCGZPFSUWZBN-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2
SMILES Code: C=CC(C1=CC=C2C=CC=CC2=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 182.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors Bioorg.Med.Chem.Lett. 10 575 PMID: 10741557
2. Orange et al (2011) IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J.Clin.Invest. 121 1535 PMID: 21383498