WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574940
Description: YM-60828 dihydrochloride is a Factor Xa (FXa) inhibitor and anticoagulant used in the treatment of venous thromboembolic disease.
MedKoo Cat#: 574940
Name: YM-60828 dihydrochloride
Chemical Formula: C27H33Cl2N5O5S
Exact Mass: 609.1579
Molecular Weight: 610.55
Elemental Analysis: C, 53.12; H, 5.45; Cl, 11.61; N, 11.47; O, 13.10; S, 5.25
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: YM 60828; YM60828; YM-60828 dihydrochloride; YM-60828 HCl; YM-60828 2HCl
IUPAC/Chemical Name: 2-[[[[7-(Aminoiminomethyl)-2-naphthalenyl]methyl][4-[[1-(1-iminoethyl)-4-piperidinyl]oxy]phenyl]amino]sulfonyl]acetic Acid Dihydrochloride
InChi Key: GKELESGQQAPAAO-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H31N5O5S.2ClH/c1-18(28)31-12-10-25(11-13-31)37-24-8-6-23(7-9-24)32(38(35,36)17-26(33)34)16-19-2-3-20-4-5-21(27(29)30)15-22(20)14-19;;/h2-9,14-15,25,28H,10-13,16-17H2,1H3,(H3,29,30)(H,33,34);2*1H
SMILES Code: O=C(O)CS(=O)(N(CC1=CC=C2C=CC(C(N)=N)=CC2=C1)C3=CC=C(OC4CCN(C(C)=N)CC4)C=C3)=O.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 610.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Sato K, Kawasaki T, Taniuchi Y, Hirayama F, Koshio H, Matsumoto Y. YM-60828, a novel factor Xa inhibitor: separation of its antithrombotic effects from its prolongation of bleeding time. Eur J Pharmacol. 1997 Nov 27;339(2-3):141-6. doi: 10.1016/s0014-2999(97)01389-7. PMID: 9473127.
2. Sato K, Kawasaki T, Hisamichi N, Taniuchi Y, Hirayama F, Koshio H, Matsumoto Y. Antithrombotic effects of YM-60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time. Br J Pharmacol. 1998 Jan;123(1):92-6. doi: 10.1038/sj.bjp.0701566. PMID: 9484858; PMCID: PMC1565130.
3. Hirayama F, Koshio H, Katayama N, Kurihara H, Taniuchi Y, Sato K, Hisamichi N, Sakai-Moritani Y, Kawasaki T, Matsumoto Y, Yanagisawa I. The discovery of YM-60828: a potent, selective and orally-bioavailable factor Xa inhibitor. Bioorg Med Chem. 2002 May;10(5):1509-23. doi: 10.1016/s0968-0896(01)00418-7. PMID: 11886813.