YM-60828 dihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574940

CAS#: 179755-65-8

Description: YM-60828 dihydrochloride is a Factor Xa (FXa) inhibitor and anticoagulant used in the treatment of venous thromboembolic disease.


Chemical Structure

img
YM-60828 dihydrochloride
CAS# 179755-65-8

Theoretical Analysis

MedKoo Cat#: 574940
Name: YM-60828 dihydrochloride
CAS#: 179755-65-8
Chemical Formula: C27H33Cl2N5O5S
Exact Mass: 609.1579
Molecular Weight: 610.55
Elemental Analysis: C, 53.12; H, 5.45; Cl, 11.61; N, 11.47; O, 13.10; S, 5.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: YM 60828; YM60828; YM-60828 dihydrochloride; YM-60828 HCl; YM-60828 2HCl

IUPAC/Chemical Name: 2-[[[[7-(Aminoiminomethyl)-2-naphthalenyl]methyl][4-[[1-(1-iminoethyl)-4-piperidinyl]oxy]phenyl]amino]sulfonyl]acetic Acid Dihydrochloride

InChi Key: GKELESGQQAPAAO-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H31N5O5S.2ClH/c1-18(28)31-12-10-25(11-13-31)37-24-8-6-23(7-9-24)32(38(35,36)17-26(33)34)16-19-2-3-20-4-5-21(27(29)30)15-22(20)14-19;;/h2-9,14-15,25,28H,10-13,16-17H2,1H3,(H3,29,30)(H,33,34);2*1H

SMILES Code: O=C(O)CS(=O)(N(CC1=CC=C2C=CC(C(N)=N)=CC2=C1)C3=CC=C(OC4CCN(C(C)=N)CC4)C=C3)=O.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 610.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Sato K, Kawasaki T, Taniuchi Y, Hirayama F, Koshio H, Matsumoto Y. YM-60828, a novel factor Xa inhibitor: separation of its antithrombotic effects from its prolongation of bleeding time. Eur J Pharmacol. 1997 Nov 27;339(2-3):141-6. doi: 10.1016/s0014-2999(97)01389-7. PMID: 9473127.

2. Sato K, Kawasaki T, Hisamichi N, Taniuchi Y, Hirayama F, Koshio H, Matsumoto Y. Antithrombotic effects of YM-60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time. Br J Pharmacol. 1998 Jan;123(1):92-6. doi: 10.1038/sj.bjp.0701566. PMID: 9484858; PMCID: PMC1565130.

3. Hirayama F, Koshio H, Katayama N, Kurihara H, Taniuchi Y, Sato K, Hisamichi N, Sakai-Moritani Y, Kawasaki T, Matsumoto Y, Yanagisawa I. The discovery of YM-60828: a potent, selective and orally-bioavailable factor Xa inhibitor. Bioorg Med Chem. 2002 May;10(5):1509-23. doi: 10.1016/s0968-0896(01)00418-7. PMID: 11886813.