GKN-43736
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555872

CAS#: 486443-73-6

Description: GKN-43736 is a HTT-LC3 linker compound. GKN-43736 interacts with both LC3 and mHTT, but not with the wild-type HTT protein. GKN-43736 reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).


Chemical Structure

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GKN-43736
CAS# 486443-73-6

Theoretical Analysis

MedKoo Cat#: 555872
Name: GKN-43736
CAS#: 486443-73-6
Chemical Formula: C15H9Br2NO3
Exact Mass: 408.89
Molecular Weight: 411.049
Elemental Analysis: C, 43.83; H, 2.21; Br, 38.88; N, 3.41; O, 11.68

Price and Availability

Size Price Availability Quantity
100mg USD 1450 2 Weeks
200mg USD 2150 2 Weeks
500mg USD 3050 2 Weeks
1g USD 4250 2 Weeks
2g USD 6950 2 Weeks
Bulk inquiry

Synonym: GKN-43736; GKN43736; GKN 43736; LC3-mHTT-IN-AN1;

IUPAC/Chemical Name: (Z)-5-bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one

InChi Key: GPKLWRHHVIBYEO-KMKOMSMNSA-N

InChi Code: InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)/b10-3-

SMILES Code: BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Accumulation of mutant proteins is a major cause of many diseases (collectively called proteopathies), and lowering the level of these proteins can be useful for treatment of these diseases.

Product Data:
Biological target: LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 30.0 72.98
DMSO 79.0 192.19
DMSO:PBS (pH 7.2) (1:3) 0.3 0.61

Preparing Stock Solutions

The following data is based on the product molecular weight 411.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, Ding C, Luo S, Dang Y, Ding Y, Fei Y, Lu B. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209. doi: 10.1038/s41586-019-1722-1. Epub 2019 Oct 30. PMID: 31666698.