WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463184

CAS#: unknown

Description: 6Br-6a is a novel inhibitor of STAT3 activation, suppressing proliferation, inducing cell cycle arrest and apoptosis in breast cancer.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 463184
Name: 6Br-6a
CAS#: unknown
Chemical Formula: C24H23BrN2O6S
Exact Mass: 546.046
Molecular Weight: 547.42
Elemental Analysis: C, 52.66; H, 4.24; Br, 14.60; N, 5.12; O, 17.54; S, 5.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 6Br-6a; 6Br 6a; 6Br6a;

IUPAC/Chemical Name: (E)-1-(4-(4-bromo-1,1-dioxidocinnamoyl)piperazin-1-yl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one


InChi Code: InChI=1S/C24H23BrN2O6S/c1-32-19-8-6-16(14-20(19)33-2)7-9-23(28)26-10-12-27(13-11-26)24(29)22-15-17-18(25)4-3-5-21(17)34(22,30)31/h3-9,14-15H,10-13H2,1-2H3/b9-7+

SMILES Code: COC1=C(OC)C=CC(/C=C/C(N(CC2)CCN2C(C(S3(=O)=O)=CC4=C3C=CC=C4Br)=O)=O)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 547.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Liu Z, Ge X, Gu Y, Huang Y, Liu H, Yu M, Liu Y. Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo. Biomed Pharmacother. 2020 Jan;121:109502. doi: 10.1016/j.biopha.2019.109502. Epub 2019 Nov 7. PMID: 31707351.