Windorphen
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MedKoo CAT#: 574935

CAS#: 19881-70-0

Description: Windorphen is a cell-permeable bis(4-methoxyphenyl)chloroacrylaldehyde whose (Z)-isomer (isomeric content 12-15%) acts as a p300-selective histone acetytransferase (HAT) inhibitor.


Chemical Structure

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Windorphen
CAS# 19881-70-0

Theoretical Analysis

MedKoo Cat#: 574935
Name: Windorphen
CAS#: 19881-70-0
Chemical Formula: C17H15ClO3
Exact Mass: 302.07
Molecular Weight: 302.750
Elemental Analysis: C, 67.44; H, 4.99; Cl, 11.71; O, 15.85

Price and Availability

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25mg USD 370 2 Weeks
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Synonym: Histone Acetyltransferase Inhibitor XII; Windorphen; WD, HAT Inhibitor XII, Wnt Pathway Inhibitor XXII

IUPAC/Chemical Name: ( E) & ( Z)-3-Chloro-2,3- bis(4-methoxyphenyl)acrylaldehyde

InChi Key: VNRALGZMXHFBPG-MSUUIHNZSA-N

InChi Code: InChI=1S/C17H15ClO3/c1-20-14-7-3-12(4-8-14)16(11-19)17(18)13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b17-16-

SMILES Code: O=C/C(C1=CC=C(OC)C=C1)=C(Cl)\C2=CC=C(OC)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 302.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Hao J, Ao A, Zhou L, Murphy CK, Frist AY, Keel JJ, Thorne CA, Kim K, Lee E, Hong CC. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell Rep. 2013 Sep 12;4(5):898-904. doi: 10.1016/j.celrep.2013.07.047. Epub 2013 Sep 5. PMID: 24012757; PMCID: PMC3923627.