URB-754
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574930

CAS#: 86672-58-4

Description: URB-754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL).

Chemical Structure

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URB-754
CAS# 86672-58-4
Instruction

Theoretical Analysis

MedKoo Cat#: 574930
Name: URB-754
CAS#: 86672-58-4
Chemical Formula: C16H14N2O2
Exact Mass: 266.11
Molecular Weight: 266.300
Elemental Analysis: C, 72.17; H, 5.30; N, 10.52; O, 12.02

Price and Availability

Size Price Availability Quantity
5mg USD 210 2 Weeks
10mg USD 345 2 Weeks
50mg USD 675 2 Weeks
100mg USD 1045 2 Weeks
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Synonym: URB754; URB 754; URB-754

IUPAC/Chemical Name: 6-methyl-2-(p-tolylamino)-4H-benzo[d][1,3]oxazin-4-one

InChi Key: GFWNGVKCDGYFKG-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14N2O2/c1-10-3-6-12(7-4-10)17-16-18-14-8-5-11(2)9-13(14)15(19)20-16/h3-9H,1-2H3,(H,17,18)

SMILES Code: Cc1ccc(cc1)Nc1nc2ccc(C)cc2c(=O)o1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 266.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Makara, J.K., Mor, M., Fegley, D., et al. Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat. Neurosci. 8(9), 1139-1141 (2005).

2. Saario, S.M., Palomäki, V., Lehtonen, M., et al. URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain. Chem. Biol. 13, 811-814 (2006).

3. Vandevoorde, S., Jonsson, K.O., Labar, G., et al. Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. Br. J. Pharmacol. 150, 186-191 (2007).

4. Tarzia, G., Antonietti, F., Duranti, A., et al. Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Ann. Chim. 97(9), 887-894 (2007).

5. Hohmann, A.G., Suplita, R.L., Bolton, N.M., et al. An endocannabinoid mechanism for stress-induced analgesia. Nature 435, 1108-1112 (2005).