WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463174
Description: IL-4 inhibitor is an inhibitor of IL-4. It binds to IL-4 with a Kd value of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay. It is selective for IL-4 over IL-13. IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes, indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
MedKoo Cat#: 463174
Name: IL-4 Inhibitor
Chemical Formula: C18H12FN3O2
Exact Mass: 321.0914
Molecular Weight: 321.3114
Elemental Analysis: C, 67.29; H, 3.76; F, 5.91; N, 13.08; O, 9.96
Synonym: IL-4 Inhibitor; IL4 Inhibitor; IL 4 Inhibitor;
IUPAC/Chemical Name: 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)nicotinonitrile
InChi Key: DWZPPBGRCDPFSS-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H12FN3O2/c19-12-4-1-10(2-5-12)15-8-13(14(9-20)18(21)22-15)11-3-6-16(23)17(24)7-11/h1-8,23-24H,(H2,21,22)
SMILES Code: N#CC1=C(N=C(C=C1C2=CC(O)=C(C=C2)O)C3=CC=C(C=C3)F)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 321.3114 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|