IL-4 Inhibitor
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MedKoo CAT#: 463174

CAS#: 1332184-63-0

Description: IL-4 inhibitor is an inhibitor of IL-4. It binds to IL-4 with a Kd value of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay. It is selective for IL-4 over IL-13. IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes, indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.


Chemical Structure

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IL-4 Inhibitor
CAS# 1332184-63-0

Theoretical Analysis

MedKoo Cat#: 463174
Name: IL-4 Inhibitor
CAS#: 1332184-63-0
Chemical Formula: C18H12FN3O2
Exact Mass: 321.0914
Molecular Weight: 321.3114
Elemental Analysis: C, 67.29; H, 3.76; F, 5.91; N, 13.08; O, 9.96

Price and Availability

Size Price Availability Quantity
1.0mg USD 230.0 2 Weeks
5.0mg USD 510.0 2 Weeks
10.0mg USD 840.0 2 Weeks
25.0mg USD 1390.0 2 Weeks
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Synonym: IL-4 Inhibitor; IL4 Inhibitor; IL 4 Inhibitor;

IUPAC/Chemical Name: 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)nicotinonitrile

InChi Key: DWZPPBGRCDPFSS-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H12FN3O2/c19-12-4-1-10(2-5-12)15-8-13(14(9-20)18(21)22-15)11-3-6-16(23)17(24)7-11/h1-8,23-24H,(H2,21,22)

SMILES Code: N#CC1=C(N=C(C=C1C2=CC(O)=C(C=C2)O)C3=CC=C(C=C3)F)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 321.3114 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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