TS-011
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574921

CAS#: 339071-18-0

Description: TS-011 is a 20-Hydroxyeicosatetraenoic acid synthesis inhibitor.

Chemical Structure

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TS-011
CAS# 339071-18-0
Instruction

Theoretical Analysis

MedKoo Cat#: 574921
Name: TS-011
CAS#: 339071-18-0
Chemical Formula: C11H14ClN3O2
Exact Mass: 255.08
Molecular Weight: 255.700
Elemental Analysis: C, 51.67; H, 5.52; Cl, 13.86; N, 16.43; O, 12.51

Price and Availability

Size Price Availability Quantity
100mg USD 255 2 Weeks
250mg USD 415 2 Weeks
1g USD 760 2 Weeks
Bulk inquiry

Synonym: TS-011; TS011; TS 011

IUPAC/Chemical Name: N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide

InChi Key: ZTXADXBIGLLOFX-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14)

SMILES Code: O/N=C/NC1=CC=C(N2CCOCC2)C(Cl)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 255.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M, Bandou K, Kametani S, Sato M, Okuyama S, Cambj-Sapunar L, Harder DR, Roman RJ. Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke. J Pharmacol Exp Ther. 2005 Jul;314(1):77-85. doi: 10.1124/jpet.105.083964. Epub 2005 Apr 14. PMID: 15831442.

2. Marumo T, Eto K, Wake H, Omura T, Nabekura J. The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. Br J Pharmacol. 2010 Nov;161(6):1391-402. doi: 10.1111/j.1476-5381.2010.00973.x. PMID: 20735406; PMCID: PMC3000662.