T2AA
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574919

CAS#: 1380782-27-3

Description: T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor that inhibits PCNA/PIP-box peptide interaction and causes DNA replication stress by stalling DNA replication forks. It inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. It also suppresses cancer cell growth.


Chemical Structure

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T2AA
CAS# 1380782-27-3

Theoretical Analysis

MedKoo Cat#: 574919
Name: T2AA
CAS#: 1380782-27-3
Chemical Formula: C15H15I2NO3
Exact Mass: 510.9141
Molecular Weight: 511.09
Elemental Analysis: C, 35.25; H, 2.96; I, 49.66; N, 2.74; O, 9.39

Price and Availability

Size Price Availability Quantity
10.0mg USD 335.0 2 Weeks
50.0mg USD 1100.0 2 Weeks
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Synonym: T2AA

IUPAC/Chemical Name: (S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)phenol

InChi Key: NKOSKXJRVWVXRI-JTQLQIEISA-N

InChi Code: InChI=1S/C15H15I2NO3/c16-13-6-9(5-10(18)8-19)7-14(17)15(13)21-12-3-1-11(20)2-4-12/h1-4,6-7,10,19-20H,5,8,18H2/t10-/m0/s1

SMILES Code: IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 511.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Punchihewa et al (2012) Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 287 14289 PMID: 22383522

T2AA

10.0mg / USD 335.0