WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574919
Description: T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor that inhibits PCNA/PIP-box peptide interaction and causes DNA replication stress by stalling DNA replication forks. It inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. It also suppresses cancer cell growth.
MedKoo Cat#: 574919
Chemical Formula: C15H15I2NO3
Exact Mass: 510.9141
Molecular Weight: 511.09
Elemental Analysis: C, 35.25; H, 2.96; I, 49.66; N, 2.74; O, 9.39
IUPAC/Chemical Name: (S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)phenol
InChi Key: NKOSKXJRVWVXRI-JTQLQIEISA-N
InChi Code: InChI=1S/C15H15I2NO3/c16-13-6-9(5-10(18)8-19)7-14(17)15(13)21-12-3-1-11(20)2-4-12/h1-4,6-7,10,19-20H,5,8,18H2/t10-/m0/s1
SMILES Code: IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 511.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Punchihewa et al (2012) Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 287 14289 PMID: 22383522