TWS-119 (TFA salt)
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MedKoo CAT#: 574915

CAS#: 1507095-58-0 (2 TFA salt)

Description: TWS-119 is an inhibitor of glycogen synthase kinase-3β (GSK-3β) that induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).


Chemical Structure

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TWS-119 (TFA salt)
CAS# 1507095-58-0 (2 TFA salt)

Theoretical Analysis

MedKoo Cat#: 574915
Name: TWS-119 (TFA salt)
CAS#: 1507095-58-0 (2 TFA salt)
Chemical Formula: C22H16F6N4O6
Exact Mass: 546.10
Molecular Weight: 546.380
Elemental Analysis: C, 48.36; H, 2.95; F, 20.86; N, 10.25; O, 17.57

Price and Availability

Size Price Availability Quantity
5mg USD 350 2 Weeks
10mg USD 615 2 Weeks
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Related CAS #: 601514-19-6 (free base)   1507095-58-0 (2 TFA salt)  

Synonym: TWS 119 TFA; TWS-119 TFA; TWS119 TFA

IUPAC/Chemical Name: 3-((6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenol bis(2,2,2-trifluoroacetate)

InChi Key: XJEFPMFFWJTJSL-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14N4O2.2C2HF3O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14;2*3-2(4,5)1(6)7/h1-10,23H,19H2,(H,20,21,22);2*(H,6,7)

SMILES Code: FC(F)(F)C(O)=O.OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1.FC(F)(F)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 546.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Ding et al (2003) Synthetic small molecules that control stem cell fate. Proc.Natl.Acad.Sci. 100 7632

2. Kordes et al (2008) Canonical wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem.Biophys.Res.Comm. 367 116