TX-1123
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574914

CAS#: 157397-06-3

Description: TX-1123 is a cell-permeable, reversible, and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as an inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC.

Chemical Structure

img
TX-1123
CAS# 157397-06-3
Instruction

Theoretical Analysis

MedKoo Cat#: 574914
Name: TX-1123
CAS#: 157397-06-3
Chemical Formula: C20H24O3
Exact Mass: 312.17
Molecular Weight: 312.410
Elemental Analysis: C, 76.89; H, 7.74; O, 15.36

Price and Availability

Size Price Availability Quantity
10mg USD 330 2 Weeks
Bulk inquiry

Synonym: PKA Inhibitor XII; TX-1123, TX 1123, TX1123

IUPAC/Chemical Name: 2-((3,5-di- tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione

InChi Key: VUEUMQIBGLKJJD-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H24O3/c1-19(2,3)14-10-12(9-13-16(21)7-8-17(13)22)11-15(18(14)23)20(4,5)6/h7-11,23H,1-6H3

SMILES Code: O=C1/C(C(C=C1)=O)=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 312.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Ohkura K, Kawaguchi Y, Tatematsu Y, Uto Y, Hori H. An Antitumor 2-Hydroxyarylidene-4-cyclopentene-1,3-Dione as a Protein Tyrosine Kinase Inhibitor: Interaction Between TX-1123 Derivatives and Src Kinase. Anticancer Res. 2016 Jul;36(7):3645-9. PMID: 27354635.

2. Hori H, Nagasawa H, Uto Y, Ohkura K, Kirk KL, Uehara Y, Shimamura M. Design of hypoxia-targeting protein tyrosine kinase inhibitor using an innovative pharmacophore 2-methylene-4-cyclopentene-1,3-dione. Biochim Biophys Acta. 2004 Mar 11;1697(1-2):29-38. doi: 10.1016/j.bbapap.2003.11.011. PMID: 15023348.

3. Hori H, Nagasawa H, Ishibashi M, Uto Y, Hirata A, Saijo K, Ohkura K, Kirk KL, Uehara Y. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorg Med Chem. 2002 Oct;10(10):3257-65. doi: 10.1016/s0968-0896(02)00160-8. PMID: 12150871.