Calcium DTPA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412112

CAS#: 2531-75-1 (calcium)

Description: Calcium DTPA is an edetate and a chelating agent used in preparing radiopharmaceuticals.


Chemical Structure

img
Calcium DTPA
CAS# 2531-75-1 (calcium)

Theoretical Analysis

MedKoo Cat#: 412112
Name: Calcium DTPA
CAS#: 2531-75-1 (calcium)
Chemical Formula: C28H44CaN6O20
Exact Mass: 824.2236
Molecular Weight: 824.76
Elemental Analysis: C, 40.78; H, 5.38; Ca, 4.86; N, 10.19; O, 38.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 2531-75-1 (calcium)   67-43-6 (free acid)  

Synonym: Calcium DTPA; Ca-DTPA; CaDTPA; Ca DTPA

IUPAC/Chemical Name: Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-, calcium salt

InChi Key: NFOCHJTZOXNSIS-UHFFFAOYSA-L

InChi Code: InChI=1S/2C14H23N3O10.Ca/c2*18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27;/h2*1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27);/q;;+2/p-2

SMILES Code: O=C([O-])CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O.O=C([O-])CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O.[Ca+2]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 824.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Nakamura M, Kido T, Hirai K, Tabo K, Tanabe Y, Kawaguchi N, Kurata A, Kido T, Yamaguchi O, Mochizuki T. What is the mid-wall linear high intensity "lesion" on cardiovascular magnetic resonance late gadolinium enhancement? J Cardiovasc Magn Reson. 2020 Sep 14;22(1):66. doi: 10.1186/s12968-020-00665-5. PMID: 32921308; PMCID: PMC7488664.

2: Bafaraj SM. Significance of nuclear medicine scan in comparison with diethylenetriamine pentaacetic acid and ultrasound imaging in diagnosing renal disorders: An observational study. Medicine (Baltimore). 2020 Sep 4;99(36):e22038. doi: 10.1097/MD.0000000000022038. PMID: 32899061; PMCID: PMC7478558.

3: Zhou W, Hu HJ, Shen B, Shen WQ, Chen H, Wu X, Yan Q, Pang PP. [Application Values of Gadolinium-ethoxybenzyl Diethylenetriaminepentaacetic Acid Enhanced Magnetic Resonance Imaging-based Radiomics in the Quantitative Assessment of Liver Reserve Function of Patients with Liver Cirrhosis]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Aug 30;42(4):459-467. Chinese. doi: 10.3881/j.issn.1000-503X.12620. PMID: 32895097.

4: Han H, Wu X, Yao L, Chen Z. Heavy metal-immobilizing bacteria combined with calcium polypeptides reduced the uptake of Cd in wheat and shifted the rhizosphere bacterial communities. Environ Pollut. 2020 Aug 18;267:115432. doi: 10.1016/j.envpol.2020.115432. Epub ahead of print. PMID: 32841909.

5: Wang C, Gao C, Maimaiti W, Li S, Yang Q, Jiang L. The features of technetium-99m-DTPA renal dynamic imaging after severe unilateral ureteral obstruction in adult rabbits. PLoS One. 2020 Aug 19;15(8):e0237443. doi: 10.1371/journal.pone.0237443. PMID: 32813713; PMCID: PMC7437917.

6: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Indium In 111 Pentetate. 2020 Aug 17. PMID: 29999782.

7: Fujita Y, Walton M, Das G, Dohnalkova A, Vanzin G, Anderko A. Impacts of anthropogenic gadolinium on the activity of the ammonia oxidizing bacterium Nitrosomonas europaea. Chemosphere. 2020 Oct;257:127250. doi: 10.1016/j.chemosphere.2020.127250. Epub 2020 Jun 3. PMID: 32600781.

8: Kim SY. Diagnosis of hepatocellular carcinoma: Which MRI contrast agent? Which diagnostic criteria? Clin Mol Hepatol. 2020 Jul;26(3):309-311. doi: 10.3350/cmh.2020.0061. Epub 2020 Jun 15. PMID: 32536046; PMCID: PMC7364363.

9: Zhang J, Winters K, Kiser K, Baboli M, Kim SG. Assessment of tumor treatment response using active contrast encoding (ACE)-MRI: Comparison with conventional DCE-MRI. PLoS One. 2020 Jun 10;15(6):e0234520. doi: 10.1371/journal.pone.0234520. PMID: 32520950; PMCID: PMC7286489.

10: Thị Hue N, Van Hop N, Thai Long H, Hai Phong N, Uyen TH, Quoc Hung L, Nhi Phuong N. Determination of Chromium in Natural Water by Adsorptive Stripping Voltammetry Using In Situ Bismuth Film Electrode. J Environ Public Health. 2020 May 14;2020:1347836. doi: 10.1155/2020/1347836. PMID: 32508934; PMCID: PMC7244981.

11: Xiao B, Wang P, Zhao Y, Liu Y, Ye Z. Nasopharyngeal carcinoma perfusion MRI: Comparison of arterial spin labeling and dynamic contrast-enhanced MRI. Medicine (Baltimore). 2020 May 29;99(22):e20503. doi: 10.1097/MD.0000000000020503. PMID: 32481470.

12: Hui CL, Mautone M. Patterns of enhancement in the hepatobiliary phase of gadoxetic acid-enhanced MRI. Br J Radiol. 2020 Aug;93(1112):20190989. doi: 10.1259/bjr.20190989. Epub 2020 Jun 1. PMID: 32462892; PMCID: PMC7446010.

13: Lin L, Hao X, Li C, Sun C, Wang X, Yin L, Zhang X, Tian J, Yang Y. Impaired glymphatic system in secondary degeneration areas after ischemic stroke in rats. J Stroke Cerebrovasc Dis. 2020 Jul;29(7):104828. doi: 10.1016/j.jstrokecerebrovasdis.2020.104828. Epub 2020 May 11. PMID: 32404284.

14: Hu MJ, Yu YX, Fan YF, Jiang YM, Hu S, Wang XM, Hu CH. [The predictive value of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI imaging features combined with quantitative parameters for the pathologic grading of hepatocellular carcinoma]. Zhonghua Yi Xue Za Zhi. 2020 May 5;100(17):1299-1304. Chinese. doi: 10.3760/cma.j.cn112137-20191021-02281. PMID: 32375436.

15: Zhao D, Tong BS, Duan ML. [In vivo dynamic changes of inner ear guinea pigs with 9.4 T esla MRI]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Apr 7;55(4):378-383. Chinese. doi: 10.3760/cma.j.cn115330-20190727-00467. PMID: 32306636.

16: Song Y, Han HB, Yang J, Wang AB, He QY, Li YY, Zhao GM, Gao YJ, Wang R, Han YX, Liu AL, Song QW. [Effect of convection enhanced delivery on the microstructure of brain extracellular space in aged rats]. Beijing Da Xue Xue Bao Yi Xue Ban. 2020 Apr 18;52(2):362-367. Chinese. doi: 10.19723/j.issn.1671-167X.2020.02.026. PMID: 32306023; PMCID: PMC7433439.

17: Liu S, Lin X, Shi X, Fang L, Huo L, Shang F, Knuuti J, Han C, Wu X, Guo R, Ding H, Zhang R, Duan H, Ding J, Xing H, Zhao X. Myocardial tissue and metabolism characterization in men with alcohol consumption by cardiovascular magnetic resonance and 11C-acetate PET/CT. J Cardiovasc Magn Reson. 2020 Apr 16;22(1):23. doi: 10.1186/s12968-020-00614-2. PMID: 32299425; PMCID: PMC7161264.

18: Shi W, Liang X, Wu N, Zhang H, Yuan X, Tan Y. Assessment of Split Renal Function Using a Combination of Contrast-Enhanced CT and Serum Creatinine Values for Glomerular Filtration Rate Estimation. AJR Am J Roentgenol. 2020 Jul;215(1):142-147. doi: 10.2214/AJR.19.22125. Epub 2020 Apr 7. PMID: 32255686.

19: Xiao L, Li MH, Dai J, Motelica-Heino M, Chen XF, Wu JL, Zhao L, Liu K, Zhang C. Assessment of earthworm activity on Cu, Cd, Pb and Zn bioavailability in contaminated soils using biota to soil accumulation factor and DTPA extraction. Ecotoxicol Environ Saf. 2020 Jun 1;195:110513. doi: 10.1016/j.ecoenv.2020.110513. Epub 2020 Mar 23. PMID: 32213370.

20: Yu Y, Dang J, Liu X, Wang L, Li S, Zhang T, Ding X. Metal-Labeled Aptamers as Novel Nanoprobes for Imaging Mass Cytometry Analysis. Anal Chem. 2020 May 5;92(9):6312-6320. doi: 10.1021/acs.analchem.9b05159. Epub 2020 Apr 1. PMID: 32208602.



Additional Information

Pentetic acid (DTPA) has strong affinity for iron but also shows affinities for other heavy metals, thereby is used in the treatment of iron-storage disease and poisoning from heavy and radioactive metals. DTPA may chelate metallic moieties of unbound, extracellular radioimmunotherapeutics, thereby aggregating radioimmunotherapeutics locally to higher concentrations, and improving tumor cell radiocytotoxicity, while sparing normal tissues from the radiocytotoxic effects. In addition, DTPA is used in radioimaing procedures when complexes with radioisotopes, ex., Tc 99m or In 111.