Xylometazoline free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412101

CAS#: 526-36-3 (free base)

Description: Xylometazoline, also spelled xylomethazoline, is a medication used to reduce symptoms of nasal congestion, allergic rhinitis, and sinusitis. Use is not recommended for more than seven days. Xylometazoline is an imidazole derivative which is designed to mimic the molecular shape of adrenaline. It binds to α1 and α2 adrenergic receptors in the nasal mucosa. Due to its sympathomimetic effects, it should not be used by people with high blood pressure, or other heart problems.

Chemical Structure

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Xylometazoline free base
CAS# 526-36-3 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 412101
Name: Xylometazoline free base
CAS#: 526-36-3 (free base)
Chemical Formula: C16H24N2
Exact Mass: 244.19
Molecular Weight: 244.380
Elemental Analysis: C, 78.64; H, 9.90; N, 11.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1218-35-5 (HCl)   526-36-3 (free base)    

Synonym: Xylometazoline free base, BA 11391; BA-11391; BA11391;

IUPAC/Chemical Name: 1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro-

InChi Key: HUCJFAOMUPXHDK-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18)

SMILES Code: CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 244.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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3: Onal M, Keles B, Erdur O, Alatas N, Onal O. Effect of Hypertonic Saline during Flexible Nasopharyngeal Laryngoscopy: A Double-Blinded, Randomized, Controlled Trial. J Invest Surg. 2020 Jun 11:1-6. doi: 10.1080/08941939.2020.1777490. Epub ahead of print. PMID: 32525416.

4: Matsukawa T, Hikasa Y. Effects of imidazoline and nonimidazoline α-adrenoceptor agonists and antagonists, including xylazine, medetomidine, dexmedetomidine, yohimbine, and atipamezole, on aggregation of feline platelets. Am J Vet Res. 2020 Feb;81(2):159-171. doi: 10.2460/ajvr.81.2.159. PMID: 31985287.

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6: Ali A, Wahlgren M, Rembratt-Svensson B, Daftani A, Falkman P, Wollmer P, Engblom J. Dehydration affects drug transport over nasal mucosa. Drug Deliv. 2019 Dec;26(1):831-840. doi: 10.1080/10717544.2019.1650848. PMID: 31401887; PMCID: PMC6713119.

7: Alaula LS, Al-Kadi M, Almajed A, Alhedaithy R. Atropine toxicity caused by erroneous intranasal administration in a pediatric patient: case report. Ann Saudi Med. 2019 Jul-Aug;39(4):279-282. doi: 10.5144/0256-4947.2019.279. Epub 2019 Aug 5. PMID: 31381360; PMCID: PMC6838643.

8: Reid JW, Rotenberg BW, Sowerby LJ. Contemporary decongestant practices of Canadian otolaryngologists for endoscopic sinus surgery. J Otolaryngol Head Neck Surg. 2019 Mar 18;48(1):15. doi: 10.1186/s40463-019-0337-8. PMID: 30885260; PMCID: PMC6421656.

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11: Unsal AIA, Basal Y, Birincioglu S, Kocaturk T, Cakmak H, Unsal A, Cakiroz G, Eliyatkın N, Yukselen O, Demirci B. Ophthalmic adverse effects of nasal decongestants on an experimental rat model. Arq Bras Oftalmol. 2018 Jan- Feb;81(1):53-58. doi: 10.5935/0004-2749.20180012. PMID: 29538595.

12: Song J. A comparison of the effects of epinephrine and xylometazoline in decreasing nasal bleeding during nasotracheal intubation. J Dent Anesth Pain Med. 2017 Dec;17(4):281-287. doi: 10.17245/jdapm.2017.17.4.281. Epub 2017 Dec 28. PMID: 29349350; PMCID: PMC5766085.

13: Red. Xylometazolin plus Dexpanthenol gegen akute Rhinitis. MMW Fortschr Med. 2018 Jan;160(1):68. German. doi: 10.1007/s15006-018-0098-8. PMID: 29335936.

14: Haldar R, Bajwa SS, Kaur J. Xylometazoline nasal drops induced anaphylaxis: An atypical perioperative complication. J Anaesthesiol Clin Pharmacol. 2017 Jul- Sep;33(3):399-401. doi: 10.4103/0970-9185.173331. PMID: 29109644; PMCID: PMC5672530.

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16: Mösges R, Shah-Hosseini K, Hucke HP, Joisten MJ. Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays. Adv Ther. 2017 Aug;34(8):1850-1858. doi: 10.1007/s12325-017-0581-0. Epub 2017 Jul 10. PMID: 28695477; PMCID: PMC5565656.

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19: Deckx L, De Sutter AI, Guo L, Mir NA, van Driel ML. Nasal decongestants in monotherapy for the common cold. Cochrane Database Syst Rev. 2016 Oct 17;10(10):CD009612. doi: 10.1002/14651858.CD009612.pub2. PMID: 27748955; PMCID: PMC6461189.

20: Wang X, Johansen SS, Nielsen MKK, Linnet K. Targeted analysis of 116 drugs in hair by UHPLC-MS/MS and its application to forensic cases. Drug Test Anal. 2017 Aug;9(8):1137-1151. doi: 10.1002/dta.2130. Epub 2016 Dec 22. PMID: 27794182.