Safranal
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MedKoo CAT#: 463112

CAS#: 116-26-7

Description: Safranal is a monoterpenoid that has been found in C. sativus and has diverse biological activities, including microtubule polymerization inhibitory, cancer cell growth inhibitory, and antioxidant properties. It decreases microtubule polymerization in a cell-free assay and inhibits the growth of HeLa cells. Safranal reduces the levels of thiobarbituric acid reactive substances and malondialdehyde in the hippocampus in a rat model of global cerebral ischemia. It also reduces convulsions induced by pentylenetetrazole in mice.


Chemical Structure

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Safranal
CAS# 116-26-7

Theoretical Analysis

MedKoo Cat#: 463112
Name: Safranal
CAS#: 116-26-7
Chemical Formula: C10H14O
Exact Mass: 150.10
Molecular Weight: 150.221
Elemental Analysis: C, 79.96; H, 9.39; O, 10.65

Price and Availability

Size Price Availability Quantity
50mg USD -2 2 Weeks
100mg USD -2 2 Weeks
200mg USD -2 2 Weeks
500mg USD -2 2 Weeks
2g USD -2 2 Weeks
1g USD 210 2 Weeks
5g USD 380 2 Weeks
10g USD 610 2 Weeks
25g USD 960 2 Weeks
Bulk inquiry

Synonym: Safranal;

IUPAC/Chemical Name: 2,6,6-trimethylcyclohexa-1,3-diene-1-carbaldehyde

InChi Key: SGAWOGXMMPSZPB-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H14O/c1-8-5-4-6-10(2,3)9(8)7-11/h4-5,7H,6H2,1-3H3

SMILES Code: O=CC1=C(C=CCC1(C)C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 150.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yousefi F, Arab FL, Rastin M, Tabasi NS, Nikkhah K, Mahmoudi M. Comparative assessment of immunomodulatory, proliferative, and antioxidant activities of crocin and crocetin on mesenchymal stem cells. J Cell Biochem. 2020 Sep 20. doi: 10.1002/jcb.29826. Epub ahead of print. PMID: 32951264.

2: Fang Q, Li Y, Liu B, Meng X, Yang Z, Yang S, Bao T, Kimani S, Gao X, Wang L. Cloning and functional characterization of a carotenoid cleavage dioxygenase 2 gene in safranal and crocin biosynthesis from Freesia hybrida. Plant Physiol Biochem. 2020 Sep;154:439-450. doi: 10.1016/j.plaphy.2020.06.035. Epub 2020 Jul 5. PMID: 32912484.

3: Moratalla-López N, Parizad S, Habibi MK, Winter S, Kalantari S, Bera S, Lorenzo C, García-Rodríguez MV, Dizadji A, Alonso GL. Impact of two different dehydration methods on saffron quality, concerning the prevalence of Saffron latent virus (SaLV) in Iran. Food Chem. 2021 Feb 1;337:127786. doi: 10.1016/j.foodchem.2020.127786. Epub 2020 Aug 6. PMID: 32795861.

4: Orio L, Alen F, Ballesta A, Martin R, Gomez de Heras R. Antianhedonic and Antidepressant Effects of Affron®, a Standardized Saffron (Crocus Sativus L.) Extract. Molecules. 2020 Jul 15;25(14):3207. doi: 10.3390/molecules25143207. PMID: 32679643; PMCID: PMC7397008.

5: Martí M, Diretto G, Aragonés V, Frusciante S, Ahrazem O, Gómez-Gómez L, Daròs JA. Efficient production of saffron crocins and picrocrocin in Nicotiana benthamiana using a virus-driven system. Metab Eng. 2020 Sep;61:238-250. doi: 10.1016/j.ymben.2020.06.009. Epub 2020 Jul 3. PMID: 32629020.

6: Farag MA, Hegazi N, Dokhalahy E, Khattab AR. Chemometrics based GC-MS aroma profiling for revealing freshness, origin and roasting indices in saffron spice and its adulteration. Food Chem. 2020 Nov 30;331:127358. doi: 10.1016/j.foodchem.2020.127358. Epub 2020 Jun 20. PMID: 32593795.

7: Giannoulaki P, Kotzakioulafi E, Chourdakis M, Hatzitolios A, Didangelos T. Impact of Crocus Sativus L. on Metabolic Profile in Patients with Diabetes Mellitus or Metabolic Syndrome: A Systematic Review. Nutrients. 2020 May 14;12(5):1424. doi: 10.3390/nu12051424. PMID: 32423173; PMCID: PMC7284534.

8: Dogra A, Kotwal P, Gour A, Bhatt S, Singh G, Mukherjee D, Nandi U. Description of Druglike Properties of Safranal and Its Chemistry behind Low Oral Exposure. ACS Omega. 2020 Apr 23;5(17):9885-9891. doi: 10.1021/acsomega.0c00160. PMID: 32391475; PMCID: PMC7203973.

9: Ali MS, Al-Lohedan HA. Spectroscopic and Molecular Docking Investigation on the Noncovalent Interaction of Lysozyme with Saffron Constituent "Safranal". ACS Omega. 2020 Apr 16;5(16):9131-9141. doi: 10.1021/acsomega.9b04291. PMID: 32363265; PMCID: PMC7191604.

10: Yue J, Wang R, Ma X, Liu J, Lu X, Balaso Thakar S, An N, Liu J, Xia E, Liu Y. Full-length transcriptome sequencing provides insights into the evolution of apocarotenoid biosynthesis in Crocus sativus. Comput Struct Biotechnol J. 2020 Mar 26;18:774-783. doi: 10.1016/j.csbj.2020.03.022. PMID: 32280432; PMCID: PMC7132054.

11: Xue Y, Jin W, Xue Y, Zhang Y, Wang H, Zhang Y, Guan S, Chu X, Zhang J. Safranal, an active constituent of saffron, ameliorates myocardial ischemia via reduction of oxidative stress and regulation of Ca2+ homeostasis. J Pharmacol Sci. 2020 Jul;143(3):156-164. doi: 10.1016/j.jphs.2020.03.005. Epub 2020 Mar 23. PMID: 32278466.

12: Shahat AS, Hassan WA, El-Sayed WM. N-Acetylcysteine and Safranal prevented the brain damage induced by hyperthyroidism in adult male rats. Nutr Neurosci. 2020 Apr 7:1-15. doi: 10.1080/1028415X.2020.1743917. Epub ahead of print. PMID: 32264788.

13: Malekzadeh S, Heidari MR, Razavi BM, Rameshrad M, Hosseinzadeh H. Effect of safranal, a constituent of saffron, on olanzapine (an atypical antipsychotic) induced metabolic disorders in rat. Iran J Basic Med Sci. 2019 Dec;22(12):1476-1482. doi: 10.22038/IJBMS.2019.13992. PMID: 32133067; PMCID: PMC7043869.

14: Mottaghipisheh J, Mahmoodi Sourestani M, Kiss T, Horváth A, Tóth B, Ayanmanesh M, Khamushi A, Csupor D. Comprehensive chemotaxonomic analysis of saffron crocus tepal and stamen samples, as raw materials with potential antidepressant activity. J Pharm Biomed Anal. 2020 May 30;184:113183. doi: 10.1016/j.jpba.2020.113183. Epub 2020 Feb 18. PMID: 32105944.

15: Almodóvar P, Briskey D, Rao A, Prodanov M, Inarejos-García AM. Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract. Evid Based Complement Alternat Med. 2020 Jan 30;2020:1575730. doi: 10.1155/2020/1575730. PMID: 32089715; PMCID: PMC7013346.

16: Fernández-Albarral JA, de Hoz R, Ramírez AI, López-Cuenca I, Salobrar-García E, Pinazo-Durán MD, Ramírez JM, Salazar JJ. Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases. Neural Regen Res. 2020 Aug;15(8):1408-1416. doi: 10.4103/1673-5374.274325. PMID: 31997799; PMCID: PMC7059587.

17: Feyzi S, Varidi M, Housaindokht MR, Es'haghi Z. Innovative method for analysis of safranal under static and dynamic conditions through combination of HS-SPME-GC technique with mathematical modelling. Phytochem Anal. 2020 Sep;31(5):564-574. doi: 10.1002/pca.2920. Epub 2020 Jan 29. PMID: 31997502.

18: Lertnimitphun P, Jiang Y, Kim N, Fu W, Zheng C, Tan H, Zhou H, Zhang X, Pei W, Lu Y, Xu H. Safranal Alleviates Dextran Sulfate Sodium-Induced Colitis and Suppresses Macrophage-Mediated Inflammation. Front Pharmacol. 2019 Nov 1;10:1281. doi: 10.3389/fphar.2019.01281. PMID: 31736758; PMCID: PMC6838343.

19: Ghazala RA, El Medney A, Meleis A, Mohie El Dien P, Samir H. Role of anti- inflammatory interventions in high-fat-diet-induced obesity. Biomed Chromatogr. 2020 Mar;34(3):e4743. doi: 10.1002/bmc.4743. Epub 2020 Jan 15. PMID: 31715013.

20: Salem AA, Lotfy M, Amin A, Ghattas MA. Characterization of human serum albumin's interactions with safranal and crocin using multi-spectroscopic and molecular docking techniques. Biochem Biophys Rep. 2019 Sep 12;20:100670. doi: 10.1016/j.bbrep.2019.100670. PMID: 31535038; PMCID: PMC6744526.