SAR-216471 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574870

CAS#: 1279829-64-9

Description: SAR-216471 hydrochloride is a P2Y12 antagonist with anti-platelet and anti-thrombotic activity.

Chemical Structure

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SAR-216471 HCl
CAS# 1279829-64-9
Instruction

Theoretical Analysis

MedKoo Cat#: 574870
Name: SAR-216471 HCl
CAS#: 1279829-64-9
Chemical Formula: C28H32Cl2N8O3
Exact Mass: 598.20
Molecular Weight: 599.520
Elemental Analysis: C, 56.10; H, 5.38; Cl, 11.83; N, 18.69; O, 8.01

Price and Availability

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10mg USD 425 2 Weeks
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Synonym: SAR-216471 hydrochloride; SAR-216471 HCl

IUPAC/Chemical Name: 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

InChi Key: UQLWHBMSQKUYAI-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H31ClN8O3.ClH/c1-4-5-24(38)21-15-30-37(18(21)2)26-9-8-25(32-33-26)31-28(40)22-16-36(23-7-6-19(29)14-20(22)23)17-27(39)35-12-10-34(3)11-13-35;/h6-9,14-16H,4-5,10-13,17H2,1-3H3,(H,31,32,40);1H

SMILES Code: O=C(C1=CN(CC(N2CCN(C)CC2)=O)C3=C1C=C(Cl)C=C3)NC4=NN=C(N5N=CC(C(CCC)=O)=C5C)C=C4.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 599.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Boldron et al (2014) N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J.Med.Chem. 57 7293 PMID: 25075638