WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463084

CAS#: unknown

Description: V30-SP-8 is a novel Mycobacterium Tuberculosis VapC-Activating Stapled Peptide, successfully penetrated Mycobacterium smegmatis cell membranes and exerted bactericidal activity at a minimum inhibitory concentration that inhibited 50% of the isolates (MIC50) < 6.25 μM.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 463084
Name: V30-SP-8
CAS#: unknown
Chemical Formula: C34H58N14O12
Exact Mass: 854.44
Molecular Weight: 854.924
Elemental Analysis: C, 47.77; H, 6.84; N, 22.94; O, 22.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: V30-SP-8; V30SP-8; V30 SP-8; V30-SP8; V30-SP 8; SLAABRHS;

IUPAC/Chemical Name: L-seryl-L-leucyl-L-alanyl-L-alanyl-L-asparaginyl-L-arginyl-L-histidyl-L-serine


InChi Code: InChI=1S/C34H58N14O12/c1-15(2)8-21(46-28(54)19(35)12-49)30(56)43-16(3)26(52)42-17(4)27(53)45-23(10-25(36)51)32(58)44-20(6-5-7-40-34(37)38)29(55)47-22(9-18-11-39-14-41-18)31(57)48-24(13-50)33(59)60/h11,14-17,19-24,49-50H,5-10,12-13,35H2,1-4H3,(H2,36,51)(H,39,41)(H,42,52)(H,43,56)(H,44,58)(H,45,53)(H,46,54)(H,47,55)(H,48,57)(H,59,60)(H4,37,38,40)/t16-,17-,19-,20-,21-,22-,23-,24-/m0/s1

SMILES Code: O=C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 854.924000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kang SM, Moon H, Han SW, Kim DH, Kim BM, Lee BJ. Structure-Based De Novo Design of Mycobacterium Tuberculosis VapC-Activating Stapled Peptides. ACS Chem Biol. 2020 Sep 18;15(9):2493-2498. doi: 10.1021/acschembio.0c00492. Epub 2020 Sep 9. PMID: 32840352.