Pyrimethanil
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574853

CAS#: 53112-28-0

Description: Pyrimethanil is a broad spectrum anilino-pyrimidine foliar fungicide.

Chemical Structure

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Pyrimethanil
CAS# 53112-28-0
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 574853
Name: Pyrimethanil
CAS#: 53112-28-0
Chemical Formula: C12H13N3
Exact Mass: 199.11
Molecular Weight: 199.260
Elemental Analysis: C, 72.33; H, 6.58; N, 21.09

Price and Availability

Size Price Availability Quantity
1g USD 210 2 Weeks
5g USD 370 2 Weeks
10g USD 585 2 Weeks
25g USD 875 2 Weeks
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Synonym: Mythos; Pyrimethanil; Penbotec; Scala

IUPAC/Chemical Name: 4,6-Dimethyl-N-phenyl-2-pyrimidinamine

InChi Key: ZLIBICFPKPWGIZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H13N3/c1-9-8-10(2)14-12(13-9)15-11-6-4-3-5-7-11/h3-8H,1-2H3,(H,13,14,15)

SMILES Code: CC1=CC(C)=NC(NC2=CC=CC=C2)=N1

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection.
In vitro activity: In vitro investigations were conducted to assess the activity of pyrimethanil, an anilinopyrimidine fungicide, against Penicillium digitatum, a common citrus fruit pathogen. Pyrimethanil at 0.20 μg/ml reduced methionine production in mycelia and inhibited the activity of cell wall-degrading enzymes, such as cellulase and pectinase. Reference: Plant Dis. 2021 Jun;105(6):1758-1764. https://pubmed.ncbi.nlm.nih.gov/33044143/
In vivo activity: This study investigated the effectiveness of pyrimethanil as a postharvest fungicide against green and blue molds caused by Penicillium digitatum and Penicillium italicum, respectively. Pyrimethanil treatments, especially at higher temperatures, significantly reduced mold development without adversely affecting the fruit's external appearance, flavor, or taste. Pyrimethanil is an effective option for mold control in citrus fruits. Reference: J Agric Food Chem. 2006 Jun 28;54(13):4721-6. https://pubmed.ncbi.nlm.nih.gov/16787020/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 130.0 652.45

Preparing Stock Solutions

The following data is based on the product molecular weight 199.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Zhang Y, Fu Y, Luo C, Zhu F. Pyrimethanil Sensitivity and Resistance Mechanisms in Penicillium digitatum. Plant Dis. 2021 Jun;105(6):1758-1764. doi: 10.1094/PDIS-08-20-1739-RE. Epub 2021 Apr 22. PMID: 33044143. 2. Cus F, Raspor P. The effect of pyrimethanil on the growth of wine yeasts. Lett Appl Microbiol. 2008 Jul;47(1):54-9. doi: 10.1111/j.1472-765X.2008.02383.x. Epub 2008 Jun 9. PMID: 18544142. 3. D'Aquino S, Schirra M, Palma A, Angioni A, Cabras P, Migheli Q. Residue levels and effectiveness of pyrimethanil vs imazalil when using heated postharvest dip treatments for control of Penicillium decay on citrus fruit. J Agric Food Chem. 2006 Jun 28;54(13):4721-6. doi: 10.1021/jf0606555. PMID: 16787020.
In vitro protocol: 1. Zhang Y, Fu Y, Luo C, Zhu F. Pyrimethanil Sensitivity and Resistance Mechanisms in Penicillium digitatum. Plant Dis. 2021 Jun;105(6):1758-1764. doi: 10.1094/PDIS-08-20-1739-RE. Epub 2021 Apr 22. PMID: 33044143.
In vivo protocol: 1. Cus F, Raspor P. The effect of pyrimethanil on the growth of wine yeasts. Lett Appl Microbiol. 2008 Jul;47(1):54-9. doi: 10.1111/j.1472-765X.2008.02383.x. Epub 2008 Jun 9. PMID: 18544142. 2. D'Aquino S, Schirra M, Palma A, Angioni A, Cabras P, Migheli Q. Residue levels and effectiveness of pyrimethanil vs imazalil when using heated postharvest dip treatments for control of Penicillium decay on citrus fruit. J Agric Food Chem. 2006 Jun 28;54(13):4721-6. doi: 10.1021/jf0606555. PMID: 16787020.

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1. Xu D, Yu G, Xi P, Kong X, Wang Q, Gao L, Jiang Z. Synergistic Effects of Resveratrol and Pyrimethanil against Botrytis cinerea on Grape. Molecules. 2018 Jun 15;23(6):1455. doi: 10.3390/molecules23061455. PMID: 29914082; PMCID: PMC6099729.