AH057

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463057

CAS#: 118499-11-9

Description: AH057 is a novel JAK inhibitor, effectively blocking the JAK/STAT pathways by directly inhibiting JAK1/2 kinase activities, and leading to compromised cell proliferation and invasion, increasing apoptosis, arrested cell cycles, and impairing tumor progression in vitro and in vivo


Chemical Structure

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AH057
CAS# 118499-11-9

Theoretical Analysis

MedKoo Cat#: 463057
Name: AH057
CAS#: 118499-11-9
Chemical Formula: C17H22N2O
Exact Mass: 270.17
Molecular Weight: 270.376
Elemental Analysis: C, 75.52; H, 8.20; N, 10.36; O, 5.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AH057; AH 057; AH-057;

IUPAC/Chemical Name: (E)-2-((6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-ylidene)amino)butan-1-ol

InChi Key: WUPPLXLZQARPFF-FBMGVBCBSA-N

InChi Code: InChI=1S/C17H22N2O/c1-3-12(10-20)18-16-6-4-5-13-14-9-11(2)7-8-15(14)19-17(13)16/h7-9,12,19-20H,3-6,10H2,1-2H3/b18-16+

SMILES Code: CCC(CO)/N=C(CCC1)/C2=C1C3=C(N2)C=CC(C)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 270.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: She S, Zhao Y, Kang B, Chen C, Chen X, Zhang X, Chen W, Dan S, Wang H, Wang YJ, Zhao J. Combined inhibition of JAK1/2 and DNMT1 by newly identified small- molecule compounds synergistically suppresses the survival and proliferation of cervical cancer cells. Cell Death Dis. 2020 Sep 7;11(9):724. doi: 10.1038/s41419-020-02934-8. PMID: 32895373; PMCID: PMC7476923.