WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574849
CAS#: 1450888-35-3
Description: PS77 is a Pkh inhibitor directed to the PIF-pocket with increased selectivity for C. albicans Pkh2.
MedKoo Cat#: 574849
Name: PS77
CAS#: 1450888-35-3
Chemical Formula: C23H18Cl2O3S2
Exact Mass: 476.0074
Molecular Weight: 477.41
Elemental Analysis: C, 57.86; H, 3.80; Cl, 14.85; O, 10.05; S, 13.43
Synonym: PS77; PS 77; PS-77
IUPAC/Chemical Name: {3-(4-Chloro-phenyl)-1-[2-(4-chloro-phenylsulfanyl)-phenyl]-3-oxo-propylsulfanyl}-acetic acid
InChi Key: VAULNRMHUJFUGY-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H18Cl2O3S2/c24-16-7-5-15(6-8-16)20(26)13-22(29-14-23(27)28)19-3-1-2-4-21(19)30-18-11-9-17(25)10-12-18/h1-12,22H,13-14H2,(H,27,28)
SMILES Code: O=C(O)CSC(C1=CC=CC=C1SC2=CC=C(Cl)C=C2)CC(C3=CC=C(Cl)C=C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 477.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Pastor-Flores D, Schulze JO, Bahí A, Giacometti R, Ferrer-Dalmau J, Passeron S, Engel M, Süss E, Casamayor A, Biondi RM. PIF-pocket as a target for C. albicans Pkh selective inhibitors. ACS Chem Biol. 2013 Oct 18;8(10):2283-92. doi: 10.1021/cb400452z. Epub 2013 Aug 22. PMID: 23911092.
2. Li J, Wang J, Hou W, Jing Z, Tian C, Han Y, Liao J, Dong MQ, Xu X. Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis. Cell Cycle. 2011 Sep 1;10(17):2946-58. doi: 10.4161/cc.10.17.15922. Epub 2011 Sep 1. PMID: 21857149.
