Org-24598 lithium salt

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574834

CAS#: 722456-08-8

Description: Org-24598 lithium salt is an inhibitor of the glial glycine transporter (GlyT1).


Chemical Structure

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Org-24598 lithium salt
CAS# 722456-08-8

Theoretical Analysis

MedKoo Cat#: 574834
Name: Org-24598 lithium salt
CAS#: 722456-08-8
Chemical Formula: C19H19F3LiNO3
Exact Mass: 373.15
Molecular Weight: 373.300
Elemental Analysis: C, 61.13; H, 5.13; F, 15.27; Li, 1.86; N, 3.75; O, 12.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Org-24598 lithium salt

IUPAC/Chemical Name: N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine lithium salt

InChi Key: VMQXVSNARQMSDL-UNTBIKODSA-M

InChi Code: InChI=1S/C19H20F3NO3.Li/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22;/h2-10,17H,11-13H2,1H3,(H,24,25);/q;+1/p-1/t17-;/m1./s1

SMILES Code: O=C([O-])CN(C)CC[C@H](C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[Li+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 373.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Bradaia et al (2004) Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J.Physiol. 559 169 PMID: 15235081

2. Beato (2008) The time course of transmitter at glycinergic synapses onto motoneurons. J.Neurosci. 28 7412 PMID: 18632945