Nitrodenafil
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574814

CAS#: 147676-99-1

Description: Nitrodenafil is a related compound of Sildenafil -- a phosphodiesterase inhibitor.


Chemical Structure

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Nitrodenafil
CAS# 147676-99-1

Theoretical Analysis

MedKoo Cat#: 574814
Name: Nitrodenafil
CAS#: 147676-99-1
Chemical Formula: C17H19N5O4
Exact Mass: 357.14
Molecular Weight: 357.370
Elemental Analysis: C, 57.14; H, 5.36; N, 19.60; O, 17.91

Price and Availability

Size Price Availability Quantity
500mg USD 375 2 Weeks
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Synonym: Nitrodenafil

IUPAC/Chemical Name: 5-(2-Ethoxy-5-nitrophenyl)-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one

InChi Key: JMINGHHRIRWKPP-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H19N5O4/c1-4-6-12-14-15(21(3)20-12)17(23)19-16(18-14)11-9-10(22(24)25)7-8-13(11)26-5-2/h7-9H,4-6H2,1-3H3,(H,18,19,23)

SMILES Code: O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC([N+]([O-])=O)=CC=C3OCC)N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Nitrodenafil is a related compound of Sildenafil -- a phosphodiesterase inhibitor.
In vitro activity: TBD
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 357.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1. Dhariwal AK, Bavdekar SB. Sildenafil in pediatric pulmonary arterial hypertension. J Postgrad Med. 2015 Jul-Sep;61(3):181-92. doi: 10.4103/0022-3859.159421. PMID: 26119438; PMCID: PMC4943407.