Nisoxetine hydrochloride

Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574813

CAS#: 57754-86-6

Description: Nisoxetine hydrochloride is a norepinephrine transporter (NET) inhibitor that inhibits norepinephrine uptake and inhibits amphetamine-induced increases in norepinephrine release. It reduces increases in locomotor activity induced by d-N-ethylamphetamine, methylphenidate, and cocaine, but not morphine and also reduces cataplexy in narcoleptic dogs.

Price and Availability

Size Price Shipping out time Quantity
5mg USD 235 2 Weeks
10mg USD 385 2 Weeks
25mg USD 650 2 Weeks
50mg USD 945 2 Weeks
100mg USD 1385 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-25. Prices are subject to change without notice.

Nisoxetine hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 574813
Name: Nisoxetine hydrochloride
CAS#: 57754-86-6
Chemical Formula: C17H22ClNO2
Exact Mass: 307.1339
Molecular Weight: 307.82
Elemental Analysis: C, 66.33; H, 7.20; Cl, 11.52; N, 4.55; O, 10.40

Synonym: Lilly 94939; Nisoxetine hydrochloride; Nisoxetine HCl; NSC 298819

IUPAC/Chemical Name: 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine hydrochloride


InChi Code: InChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1. Torres, G.E., Gainetdinov, R.R., and Caron, M.G. Plasma membrane monoamine transporters: Structure, regulation and function. Nat. Rev. Neurosci. 4(1), 13-25 (2003).

2. Tyler, T.D., and Tessel, R.E. Amphetamine’s locomotor-stimulant and noreprinephrine-releasing effects: Evidence for selective antagonism by nisoxetine. Psychopharmacology (Berl) 64(3), 291-296 (1979).

3. Tyler, T.D., and Tessel, R.E. Norepinephrine uptake inhibitors as biochemically and behaviorally selective antagonists of the locomotor stimulation induced by indirectly acting sympathomimetic aminetic amines in mice. Psychopharmacology (Berl) 69(1), 27-34 (1980).

4. Foutz, A.S., Delashaw, J.B., Jr., Guilleminault, C., et al. Monoaminergic mechanisms and experimental cataplexy. Ann. Neurol. 10(4), 369-376 (1981).