M-62812
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574805

CAS#: 613263-00-6

Description: M-62812 is a TLR4 inhibitor that inhibits LPS-induced NF-κB activation in HEK293 cells and LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs.


Chemical Structure

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M-62812
CAS# 613263-00-6

Theoretical Analysis

MedKoo Cat#: 574805
Name: M-62812
CAS#: 613263-00-6
Chemical Formula: C13H13Cl2N3OS
Exact Mass: 329.0156
Molecular Weight: 330.23
Elemental Analysis: C, 47.28; H, 3.97; Cl, 21.47; N, 12.72; O, 4.84; S, 9.71

Price and Availability

Size Price Availability Quantity
10.0mg USD 300.0 2 Weeks
50.0mg USD 950.0 2 Weeks
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Synonym: M-62812; M62812; M 62812

IUPAC/Chemical Name: 6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride

InChi Key: SMTKPLISDFNJDJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H11N3OS.2ClH/c14-10-3-1-2-4-11(10)17-8-5-6-9-12(7-8)18-16-13(9)15;;/h1-7H,14H2,(H2,15,16);2*1H

SMILES Code: NC1=NSC2=C1C=CC(OC3=CC=CC=C3N)=C2.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 330.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Nakamura et al (2007) Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID: 17588563

M-62812

10.0mg / USD 300.0