ZLY032 | CAS#2314465-67-1

ZLY032
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462928

CAS#: 2314465-67-1

Description: ZLY032 is a dual agonist of free fatty acid receptor 1 and peroxisome proliferator-activated receptor δ. It is selective for FFAR1 and PPARδ over PPARα and PPARγ. ZLY032 reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in the ob/ob mouse model of metabolic disease. It reduces hepatic steatosis and plasma alanine transaminase and aspartate aminotransferase levels in a mouse model of non-alcoholic steatohepatitis induced by a methionine and choline-deficient diet at the same dose.

Chemical Structure

ZLY032

CAS# 2314465-67-1

Instruction

Theoretical Analysis

MedKoo Cat#: 462928
Name: ZLY032
CAS#: 2314465-67-1
Chemical Formula: C22H18F3NO4S
Exact Mass: 449.09
Molecular Weight: 449.444
Elemental Analysis: C, 58.79; H, 4.04; F, 12.68; N, 3.12; O, 14.24; S, 7.13

Price and Availability

Size	Price	Availability
100mg	USD -2	2 Weeks
200mg	USD -2	2 Weeks
500mg	USD -2	2 Weeks
1g	USD -2	2 Weeks
2g	USD -2	2 Weeks
5mg	USD 220	2 Weeks
10mg	USD 360	2 Weeks
25mg	USD 610	2 Weeks
50mg	USD 950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: ZLY 032; ZLY-032;

IUPAC/Chemical Name: (S)-2-(6-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

InChi Key: YBBZJHLFUPKHJD-CQSZACIVSA-N

InChi Code: InChI=1S/C22H18F3NO4S/c1-12-19(31-21(26-12)13-2-4-15(5-3-13)22(23,24)25)11-29-16-6-7-17-14(8-20(27)28)10-30-18(17)9-16/h2-7,9,14H,8,10-11H2,1H3,(H,27,28)/t14-/m1/s1

SMILES Code: CC1=C(COC2=CC=C3[C@@H](COC3=C2)CC(O)=O)SC(C4=CC=C(C=C4)C(F)(F)F)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 449.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Li Z, Zhou Z, Hu L, Deng L, Ren Q, Zhang L. ZLY032, the first-in-class dual FFA1/PPARδ agonist, improves glucolipid metabolism and alleviates hepatic fibrosis. Pharmacol Res. 2020 Sep;159:105035. doi: 10.1016/j.phrs.2020.105035. Epub 2020 Jun 17. PMID: 32562818.

Your view history

ZLY032 featured