WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462928
Description: ZLY032 is a dual agonist of free fatty acid receptor 1 and peroxisome proliferator-activated receptor δ. It is selective for FFAR1 and PPARδ over PPARα and PPARγ. ZLY032 reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in the ob/ob mouse model of metabolic disease. It reduces hepatic steatosis and plasma alanine transaminase and aspartate aminotransferase levels in a mouse model of non-alcoholic steatohepatitis induced by a methionine and choline-deficient diet at the same dose.
MedKoo Cat#: 462928
Chemical Formula: C22H18F3NO4S
Exact Mass: 449.0909
Molecular Weight: 449.4442
Elemental Analysis: C, 58.79; H, 4.04; F, 12.68; N, 3.12; O, 14.24; S, 7.13
Synonym: ZLY 032; ZLY-032;
IUPAC/Chemical Name: (S)-2-(6-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid
InChi Key: YBBZJHLFUPKHJD-CQSZACIVSA-N
InChi Code: InChI=1S/C22H18F3NO4S/c1-12-19(31-21(26-12)13-2-4-15(5-3-13)22(23,24)25)11-29-16-6-7-17-14(8-20(27)28)10-30-18(17)9-16/h2-7,9,14H,8,10-11H2,1H3,(H,27,28)/t14-/m1/s1
SMILES Code: CC1=C(COC2=CC=C3[C@@H](COC3=C2)CC(O)=O)SC(C4=CC=C(C=C4)C(F)(F)F)=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 449.4442 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Li Z, Zhou Z, Hu L, Deng L, Ren Q, Zhang L. ZLY032, the first-in-class dual FFA1/PPARδ agonist, improves glucolipid metabolism and alleviates hepatic fibrosis. Pharmacol Res. 2020 Sep;159:105035. doi: 10.1016/j.phrs.2020.105035. Epub 2020 Jun 17. PMID: 32562818.