Ambinine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462889

CAS#: 96935-26-1

Description: Ambinine is the major alkaloid of the tuber of Corydalis ambigua var. amurensis. It has protective effects on H9C2 myocardial cells.


Chemical Structure

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Ambinine
CAS# 96935-26-1

Theoretical Analysis

MedKoo Cat#: 462889
Name: Ambinine
CAS#: 96935-26-1
Chemical Formula: C23H27NO6
Exact Mass: 413.18
Molecular Weight: 413.470
Elemental Analysis: C, 66.81; H, 6.58; N, 3.39; O, 23.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ambinine;

IUPAC/Chemical Name: 4,9,10-trimethoxy-5b,12-dimethyl-5b,6,7,11b,12,13-hexahydrobenzo[c][1,3]dioxolo[4,5-i]phenanthridin-6-ol

InChi Key: CUVAOVCIXOPMNR-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H27NO6/c1-23-15-9-18(28-5)21-20(29-11-30-21)14(15)10-24(2)22(23)13-8-17(27-4)16(26-3)6-12(13)7-19(23)25/h6,8-9,19,22,25H,7,10-11H2,1-5H3

SMILES Code: COc1c(OC)cc2c(CC(C3(C2N(Cc4c3cc(OC)c5c4OCO5)C)C)O)c1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 413.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chang S, Yang Z, Han N, Liu Z, Yin J. The antithrombotic, anticoagulant activity and toxicity research of ambinine, an alkaloid from the tuber of Corydalis ambigua var. amurensis. Regul Toxicol Pharmacol. 2018 Jun;95:175-181. doi: 10.1016/j.yrtph.2018.03.004. Epub 2018 Mar 7. PMID: 29524465.

2: Liu Z, Chang S, Guan X, Han N, Yin J. The metabolites of Ambinine, a benzo[c]phenanthridine alkaloid, in rats identified by ultra-performance liquid chromatography-quadrupoletime-of-flight mass spectrometry (UPLC/Q-TOF-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:226-233. doi: 10.1016/j.jchromb.2016.08.018. Epub 2016 Aug 12. PMID: 27570218.

3: Cui Z, Qi ML, Lin L, Yu DQ. [The structure of ambinine isolated from Corydalis ambigua Cham. et Schltd]. Yao Xue Xue Bao. 1984 Dec;19(12):904-8. Chinese. PMID: 6549570.