WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462880

CAS#: 53716-50-0

Description: Oxfendazole is a benzimidazole anthelmintic. In vivo, oxfendazole is curative in pig models of H. rubidus or A. suum infection when administered at doses of 3 and 6 mg/kg, respectively. It is lethal to H. contortus and T. circumcincta when administered to infected cattle. Formulations containing oxfendazole have been used in the treatment and prevention of helminth infections in livestock.

Chemical Structure

CAS# 53716-50-0

Theoretical Analysis

MedKoo Cat#: 462880
Name: Oxfendazole
CAS#: 53716-50-0
Chemical Formula: C15H13N3O3S
Exact Mass: 315.0678
Molecular Weight: 315.347
Elemental Analysis: C, 57.13; H, 4.16; N, 13.33; O, 15.22; S, 10.17

Price and Availability

Size Price Availability Quantity
5.0mg USD 230.0 2 Weeks
10.0mg USD 380.0 2 Weeks
25.0mg USD 650.0 2 Weeks
50.0mg USD 1020.0 2 Weeks
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Synonym: Oxfenbendazole; Fenbendazole sulfoxide; HOE 8105; HOE8105; HOE-8105;

IUPAC/Chemical Name: methyl (6-(phenylsulfinyl)-1H-benzo[d]imidazol-2-yl)carbamate


InChi Code: InChI=1S/C15H13N3O3S/c1-21-15(19)18-14-16-12-8-7-11(9-13(12)17-14)22(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 315.347 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Son DS, Lee ES, Adunyah SE. The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs. Immune Netw. 2020 Aug 4;20(4):e29. doi: 10.4110/in.2020.20.e29. PMID: 32895616; PMCID: PMC7458798.

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4: Megha GK, Aulakh RS, Singh BB. Effect of oxfendazole to control Taenia solium cysticercosis in pigs in Punjab state of India. J Parasit Dis. 2020 Sep;44(3):553-558. doi: 10.1007/s12639-020-01228-2. Epub 2020 May 4. PMID: 32801507; PMCID: PMC7410941.

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10: Cho-Ngwa F, Mbah GE, Ayiseh RB, Ndi EM, Monya E, Tumanjong IM, Mainsah EN, Sakanari J, Lustigman S. Development and validation of an Onchocerca ochengi adult male worm gerbil model for macrofilaricidal drug screening. PLoS Negl Trop Dis. 2019 Jul 1;13(7):e0007556. doi: 10.1371/journal.pntd.0007556. PMID: 31260456; PMCID: PMC6625737.

11: Viviani P, Lifschitz AL, Luque SE, Lloberas MM, Maté ML, Cardozo PA, Lanusse CE, Virkel GL. Pharmacologic interaction between oxfendazole and triclabendazole: In vitro biotransformation and systemic exposure in sheep. Exp Parasitol. 2019 Sep;204:107718. doi: 10.1016/j.exppara.2019.107718. Epub 2019 Jun 12. PMID: 31201779.

12: Ngowi HA, Winkler AS, Braae UC, Mdegela RH, Mkupasi EM, Kabululu ML, Lekule FP, Johansen MV. Taenia solium taeniosis and cysticercosis literature in Tanzania provides research evidence justification for control: A systematic scoping review. PLoS One. 2019 Jun 5;14(6):e0217420. doi: 10.1371/journal.pone.0217420. PMID: 31166983; PMCID: PMC6550401.

13: Türkan F. Investigation of the toxicological and inhibitory effects of some benzimidazole agents on acetylcholinesterase and butyrylcholinesterase enzymes. Arch Physiol Biochem. 2019 May 28:1-5. doi: 10.1080/13813455.2019.1618341. Epub ahead of print. PMID: 31135232.

14: Kabululu ML, Ngowi HA, Kimera SI, Lekule FP, Kimbi EC, Johansen MV. Effectiveness of an integrated intervention in the control of endo- and ectoparasites of pigs kept by smallholder farmers in Mbeya rural and Mbozi districts, Tanzania. Vet Parasitol Reg Stud Reports. 2018 Aug;13:64-73. doi: 10.1016/j.vprsr.2018.03.009. Epub 2018 Apr 3. PMID: 31014892.

15: Bach T, Bae S, D'Cunha R, Winokur P, An G. Development and validation of a simple, fast, and sensitive LC/MS/MS method for the quantification of oxfendazole in human plasma and its application to clinical pharmacokinetic study. J Pharm Biomed Anal. 2019 Jul 15;171:111-117. doi: 10.1016/j.jpba.2019.03.048. Epub 2019 Mar 26. PMID: 30981954; PMCID: PMC6545882.

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17: Ceballos L, Canton C, Cadenazzi G, Virkel G, Dominguez P, Moreno L, Lanusse C, Alvarez L. Oxfendazole kinetics in pigs: In vivo assessment of its pattern of accumulation in Ascaris suum. Exp Parasitol. 2019 Apr;199:52-58. doi: 10.1016/j.exppara.2019.02.017. Epub 2019 Mar 1. PMID: 30831078.

18: Poudel I, Sah K, Subedi S, Kumar Singh D, Kushwaha P, Colston A, Gauci CG, Donadeu M, Lightowlers MW. Implementation of a practical and effective pilot intervention against transmission of Taenia solium by pigs in the Banke district of Nepal. PLoS Negl Trop Dis. 2019 Feb 25;13(2):e0006838. doi: 10.1371/journal.pntd.0006838. PMID: 30802248; PMCID: PMC6405169.

19: An G, Murry DJ, Gajurel K, Bach T, Deye G, Stebounova LV, Codd EE, Horton J, Gonzalez AE, Garcia HH, Ince D, Hodgson-Zingman D, Nomicos EYH, Conrad T, Kennedy J, Jones W, Gilman RH, Winokur P. Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo- Controlled First-in-Human Single-Dose Escalation Study. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02255-18. doi: 10.1128/AAC.02255-18. PMID: 30745383; PMCID: PMC6437481.

20: Xu D, Tian W, Jiang C, Huang Z, Zheng S. The anthelmintic agent oxfendazole inhibits cell growth in non‑small cell lung cancer by suppressing c‑Src activation. Mol Med Rep. 2019 Apr;19(4):2921-2926. doi: 10.3892/mmr.2019.9897. Epub 2019 Jan 28. PMID: 30720086.