ICI-63197
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574744

CAS#: 27277-00-5

Description: ICI-63197 is a phosphodiesterase (PDE) 4 inhibitor and antidepressant.


Chemical Structure

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ICI-63197
CAS# 27277-00-5

Theoretical Analysis

MedKoo Cat#: 574744
Name: ICI-63197
CAS#: 27277-00-5
Chemical Formula: C9H13N5O
Exact Mass: 207.112
Molecular Weight: 207.24
Elemental Analysis: C, 52.16; H, 6.32; N, 33.79; O, 7.72

Price and Availability

Size Price Availability Quantity
10.0mg USD 300.0 2 Weeks
50.0mg USD 940.0 2 Weeks
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Synonym: ICI 63197; ICI-63197; ICI63197

IUPAC/Chemical Name: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one

InChi Key: UQDVRVNMIJAGRK-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)

SMILES Code: O=C1N(CCC)C2=NC(N)=NN2C=C1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 207.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Kaulen et al (1989) Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram. Brain Res. 503 229 PMID: 2557965

2. Wachtel (1983) Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology 22 267 PMID: 6302550

3. Zhao et al (2003) Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram J.Pharmacol.Exp.Ther. 305 565 PMID: 12704225