U 88204

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462843

CAS#: 136816-76-7

Description: U 88204 is a non-nucleoside HIV-1 reverse transcriptase inhibitor.


Chemical Structure

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U 88204
CAS# 136816-76-7

Theoretical Analysis

MedKoo Cat#: 462843
Name: U 88204
CAS#: 136816-76-7
Chemical Formula: C21H25N5O
Exact Mass: 363.21
Molecular Weight: 363.465
Elemental Analysis: C, 69.40; H, 6.93; N, 19.27; O, 4.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: U-88204; U-88204E;

IUPAC/Chemical Name: (1H-indol-2-yl)(4-(3-(isopropylamino)pyridin-2-yl)piperazin-1-yl)methanone

InChi Key: ASOMNDIOOKDVDC-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H25N5O/c1-15(2)23-18-8-5-9-22-20(18)25-10-12-26(13-11-25)21(27)19-14-16-6-3-4-7-17(16)24-19/h3-9,14-15,23-24H,10-13H2,1-2H3

SMILES Code: CC(C)NC1=CC=CN=C1N(CC2)CCN2C(C3=CC4=CC=CC=C4N3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 363.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dueweke TJ, Kézdy FJ, Waszak GA, Deibel MR Jr, Tarpley WG. The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase. J Biol Chem. 1992 Jan 5;267(1):27-30. PMID: 1370445.

2: Vasudevachari MB, Battista C, Lane HC, Psallidopoulos MC, Zhao B, Cook J, Palmer JR, Romero DL, Tarpley WG, Salzman NP. Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors. Virology. 1992 Sep;190(1):269-77. doi: 10.1016/0042-6822(92)91213-e. PMID: 1382341.

3: Balzarini J, Karlsson A, Meichsner C, Paessens A, Riess G, De Clercq E, Kleim JP. Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720. J Virol. 1994 Dec;68(12):7986-92. doi: 10.1128/JVI.68.12.7986-7992.1994. PMID: 7525984; PMCID: PMC237261.

4: Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Palmer JR, Thomas RC, Aristoff PA, et al. Kinetic studies with the non- nucleoside HIV-1 reverse transcriptase inhibitor U-88204E. Biochemistry. 1993 Jul 6;32(26):6548-54. doi: 10.1021/bi00077a008. PMID: 7687145.