Cyclamidomycin | CAS#35663-85-5 | antibiotic

Cyclamidomycin
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462811

CAS#: 35663-85-5

Description: Cyclamidomycin is an antibiotic. It also functions as an inhibitor of nucleoside diphosphokinase of Escherichia coli.

Chemical Structure

Cyclamidomycin

CAS# 35663-85-5

Instruction

Theoretical Analysis

MedKoo Cat#: 462811
Name: Cyclamidomycin
CAS#: 35663-85-5
Chemical Formula: C7H10N2O
Exact Mass: 138.08
Molecular Weight: 138.170
Elemental Analysis: C, 60.85; H, 7.30; N, 20.28; O, 11.58

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 900	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NSC 121234; NSC 121234; NSC 121234; Pyracrimycin A; Desdanine;

IUPAC/Chemical Name: (E)-3-(3,4-dihydro-2H-pyrrol-5-yl)acrylamide

InChi Key: SJFPWBFXBOZGTB-ONEGZZNKSA-N

InChi Code: InChI=1S/C7H10N2O/c8-7(10)4-3-6-2-1-5-9-6/h3-4H,1-2,5H2,(H2,8,10)/b4-3+

SMILES Code: NC(/C=C/C1=NCCC1)=O

Appearance: Solid powder

Purity: >90% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 138.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Takahashi S, Nakajima M, Ikeda Y, Kondo S, Hamada M. A new antibiotic, cyclamidomycin. J Antibiot (Tokyo). 1971 Dec;24(12):902-3. doi: 10.7164/antibiotics.24.902. PMID: 5140536.

2: Saeki T, Hori M, Umezawa H. Cyclamidomycin (desdanine), an inhibitor of nucleoside diphosphokinase of Escherichia coli. J Antibiot (Tokyo). 1972 Jun;25(6):343-9. doi: 10.7164/antibiotics.25.343. PMID: 4568012.

3: Argoudelis AD, Hoeksema H, Whaley HA. Identity of desdanine pyracrimycin A and cyclamidomycin. J Antibiot (Tokyo). 1972 Jul;25(7):432-3. doi: 10.7164/antibiotics.25.432. PMID: 4661099.

4: Nielsen JB, Gren T, Mohite OS, Jørgensen TS, Klitgaard AK, Mourched AS, Blin K, Oves-Costales D, Genilloud O, Larsen TO, Tanner D, Weber T, Gotfredsen CH, Charusanti P. Identification of the Biosynthetic Gene Cluster for Pyracrimycin A, an Antibiotic Produced by Streptomyces sp. ACS Chem Biol. 2022 Sep 16;17(9):2411-2417. doi: 10.1021/acschembio.2c00480. Epub 2022 Aug 30. PMID: 36040247.

5: Coronelli C, Tamoni G, Beretta G, Lancini GC. Production, isolation and properties of pyracrimycin A, a new antibiotic from Streptomyces eridani N. SP. J Antibiot (Tokyo). 1971 Aug;24(8):491-6. doi: 10.7164/antibiotics.24.491. PMID: 4937286.

6: Coronelli C, Vigevani A, Cavalleri B, Gallo GG. Structure determination of pyracrimycin A, a new antibiotic substance. J Antibiot (Tokyo). 1971 Aug;24(8):497-502. doi: 10.7164/antibiotics.24.497. PMID: 5092784.

7: Cavalleri B, Volpe G, Pallanza R. Su alcuni composti correlati alla piracrimicina A [Some compounds correlated to pyracrimycin A]. Farmaco Sci. 1975 Feb;30(2):110-21. Italian. PMID: 1123033.

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Cyclamidomycin featured