Tyromycin A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462782

CAS#: 141364-77-4

Description: Tyromycin A is an inhibitor of leucine and cysteine aminopeptidases.

Chemical Structure

Tyromycin A
CAS# 141364-77-4

Theoretical Analysis

MedKoo Cat#: 462782
Name: Tyromycin A
CAS#: 141364-77-4
Chemical Formula: C26H38O6
Exact Mass: 446.2668
Molecular Weight: 446.584
Elemental Analysis: C, 69.93; H, 8.58; O, 21.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Tyromycin A;

IUPAC/Chemical Name: 4,4'-(hexadecane-1,16-diyl)bis(3-methylfuran-2,5-dione)


InChi Code: InChI=1S/C26H38O6/c1-19-21(25(29)31-23(19)27)17-15-13-11-9-7-5-3-4-6-8-10-12-14-16-18-22-20(2)24(28)32-26(22)30/h3-18H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 446.584 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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1: Chepkirui C, Cheng T, Sum WC, Matasyoh JC, Decock C, Praditya DF, Wittstein K, Steinmann E, Stadler M. Skeletocutins A-L: Antibacterial Agents from the Kenyan Wood-Inhabiting Basidiomycete, Skeletocutis sp. J Agric Food Chem. 2019 Aug 7;67(31):8468-8475. doi: 10.1021/acs.jafc.9b02598. Epub 2019 Jul 29. PMID: 31310114.

2: Mangaleswaran S, Argade NP. A facile synthesis of naturally occurring aminopeptidase inhibitor tyromycin A. J Org Chem. 2001 Jul 27;66(15):5259-61. doi: 10.1021/jo010260e. PMID: 11463284.

3: Weber W, Semar M, Anke T, Bross M, Steglich W. Tyromycin A: a novel inhibitor of leucine and cysteine aminopeptidases from Tyromyces lacteus. Planta Med. 1992 Feb;58(1):56-9. doi: 10.1055/s-2006-961390. PMID: 1620745.

4: Cheng T, Chepkirui C, Decock C, Matasyoh JC, Stadler M. Skeletocutins M-Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa. Beilstein J Org Chem. 2019 Nov 19;15:2782-2789. doi: 10.3762/bjoc.15.270. PMID: 31807212; PMCID: PMC6880814.