WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462782
CAS#: 141364-77-4
Description: Tyromycin A is an inhibitor of leucine and cysteine aminopeptidases.
MedKoo Cat#: 462782
Name: Tyromycin A
CAS#: 141364-77-4
Chemical Formula: C26H38O6
Exact Mass: 446.2668
Molecular Weight: 446.584
Elemental Analysis: C, 69.93; H, 8.58; O, 21.50
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Synonym: Tyromycin A;
IUPAC/Chemical Name: 4,4'-(hexadecane-1,16-diyl)bis(3-methylfuran-2,5-dione)
InChi Key: ZOXQKIRYCLFUCD-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H38O6/c1-19-21(25(29)31-23(19)27)17-15-13-11-9-7-5-3-4-6-8-10-12-14-16-18-22-20(2)24(28)32-26(22)30/h3-18H2,1-2H3
SMILES Code: CC1=C(C(OC1=O)=O)CCCCCCCCCCCCCCCCC2=C(C(OC2=O)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 446.584 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Chepkirui C, Cheng T, Sum WC, Matasyoh JC, Decock C, Praditya DF, Wittstein K, Steinmann E, Stadler M. Skeletocutins A-L: Antibacterial Agents from the Kenyan Wood-Inhabiting Basidiomycete, Skeletocutis sp. J Agric Food Chem. 2019 Aug 7;67(31):8468-8475. doi: 10.1021/acs.jafc.9b02598. Epub 2019 Jul 29. PMID: 31310114.
2: Mangaleswaran S, Argade NP. A facile synthesis of naturally occurring aminopeptidase inhibitor tyromycin A. J Org Chem. 2001 Jul 27;66(15):5259-61. doi: 10.1021/jo010260e. PMID: 11463284.
3: Weber W, Semar M, Anke T, Bross M, Steglich W. Tyromycin A: a novel inhibitor of leucine and cysteine aminopeptidases from Tyromyces lacteus. Planta Med. 1992 Feb;58(1):56-9. doi: 10.1055/s-2006-961390. PMID: 1620745.
4: Cheng T, Chepkirui C, Decock C, Matasyoh JC, Stadler M. Skeletocutins M-Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa. Beilstein J Org Chem. 2019 Nov 19;15:2782-2789. doi: 10.3762/bjoc.15.270. PMID: 31807212; PMCID: PMC6880814.
