WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462757

CAS#: 105129-00-8

Description: alpha-Lactorphin is a tetrapeptide that lowers blood pressure in conscious adult spontaneously hypertensive rats. It is originally released from milk protein alpha-lactalbumin by enzymatic hydrolysis.

Chemical Structure

CAS# 105129-00-8

Theoretical Analysis

MedKoo Cat#: 462757
Name: alpha-Lactorphin
CAS#: 105129-00-8
Chemical Formula: C26H35N5O5
Exact Mass: 497.2638
Molecular Weight: 497.596
Elemental Analysis: C, 62.76; H, 7.09; N, 14.07; O, 16.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Tyr-gly-leu-phe;

IUPAC/Chemical Name: (2S)-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-(2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)acetamido)-3-methylpentanamide


InChi Code: InChI=1S/C26H35N5O5/c1-3-16(2)23(26(36)30-21(24(28)34)14-17-7-5-4-6-8-17)31-22(33)15-29-25(35)20(27)13-18-9-11-19(32)12-10-18/h4-12,16,20-21,23,32H,3,13-15,27H2,1-2H3,(H2,28,34)(H,29,35)(H,30,36)(H,31,33)/t16?,20-,21-,23-/m0/s1

SMILES Code: CCC([C@@H](C(N[C@H](C(N)=O)Cc1ccccc1)=O)NC(CNC([C@H](Cc2ccc(O)cc2)N)=O)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 497.596 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sipola M, Finckenberg P, Vapaatalo H, Pihlanto-Leppälä A, Korhonen H, Korpela R, Nurminen ML. Alpha-lactorphin and beta-lactorphin improve arterial function in spontaneously hypertensive rats. Life Sci. 2002 Aug 2;71(11):1245-53. doi: 10.1016/s0024-3205(02)01793-9. PMID: 12106590.

2: Nurminen ML, Sipola M, Kaarto H, Pihlanto-Leppälä A, Piilola K, Korpela R, Tossavainen O, Korhonen H, Vapaatalo H. Alpha-lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Life Sci. 2000;66(16):1535-43. doi: 10.1016/s0024-3205(00)00471-9. PMID: 10794501.

3: Mullally MM, Meisel H, FitzGerald RJ. Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol Chem Hoppe Seyler. 1996 Apr;377(4):259-60. doi: 10.1515/bchm3.1996.377.4.259. PMID: 8737991.

4: FitzGerald RJ, Meisel H. Lactokinins: whey protein-derived ACE inhibitory peptides. Nahrung. 1999 Jun;43(3):165-7. doi: 10.1002/(SICI)1521-3803(19990601)43:3<165::AID-FOOD165>3.0.CO;2-2. PMID: 10399349.

5: Bordenave S, Sannier F, Ricart G, Piot JM. Continuous hydrolysis of goat whey in an ultrafiltration reactor: generation of alpha-lactorphin. Prep Biochem Biotechnol. 1999 May;29(2):189-202. doi: 10.1080/10826069908544890. PMID: 10231897.

6: Martínez-Maqueda D, Miralles B, De Pascual-Teresa S, Reverón I, Muñoz R, Recio I. Food-derived peptides stimulate mucin secretion and gene expression in intestinal cells. J Agric Food Chem. 2012 Sep 5;60(35):8600-5. doi: 10.1021/jf301279k. Epub 2012 Aug 23. PMID: 22916966.