MC-352

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462730

CAS#: 127521-69-1

Description: MC-352, also known as 3,4'-Dideoxy-5O-mycaminosyltylonolide, is a 16-membered macrolide antibiotic.

Chemical Structure

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MC-352
CAS# 127521-69-1
Instruction

Theoretical Analysis

MedKoo Cat#: 462730
Name: MC-352
CAS#: 127521-69-1
Chemical Formula: C31H51NO8
Exact Mass: 565.36
Molecular Weight: 565.748
Elemental Analysis: C, 65.81; H, 9.09; N, 2.48; O, 22.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MC-352; MC352; MC 352;

IUPAC/Chemical Name: 2-((5S,6R,7R,9R,11E,13Z,15R,16R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-dien-7-yl)acetaldehyde

InChi Key: IBYMOKAONAMZRG-RTBKVJJVSA-N

InChi Code: InChI=1S/C31H51NO8/c1-8-27-24(18-34)15-19(2)9-11-26(35)21(4)16-23(13-14-33)30(20(3)10-12-28(36)39-27)40-31-29(37)25(32(6)7)17-22(5)38-31/h9,11,14-15,20-25,27,29-31,34,37H,8,10,12-13,16-18H2,1-7H3/b11-9+,19-15-/t20-,21+,22+,23-,24+,25-,27+,29+,30+,31-/m0/s1

SMILES Code: CC[C@H]1OC(CC[C@@H]([C@H]([C@H](C[C@H](C(/C=C/C(C)=C\[C@@H]1CO)=O)C)CC=O)O[C@@H]2O[C@@H](C[C@H](N(C)C)[C@H]2O)C)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 565.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kageyama S, Tsuchiya T, Umezawa S, Takeuchi T. Synthesis of 3,4'-dideoxymycaminosyl tylonolide, a novel type of macrolide derivative. J Antibiot (Tokyo). 1992 Jan;45(1):144-6. doi: 10.7164/antibiotics.45.144. PMID: 1548187.

2: Chin NX, Neu HC. In vitro activity of MC-352, a new 16-membered macrolide. Antimicrob Agents Chemother. 1992 Aug;36(8):1699-702. doi: 10.1128/aac.36.8.1699. PMID: 1416853; PMCID: PMC192033.

3: Kageyama S, Tsuchiya T. Synthesis of 2-C-methyl derivatives of 3,4'-dideoxymycaminosyltylonolide, a novel type of 16-membered macrolide antibiotic. J Antibiot (Tokyo). 1994 Aug;47(8):955-6. doi: 10.7164/antibiotics.47.955. PMID: 7928687.