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MedKoo CAT#: 462566

CAS#: 1454925-59-7

Description: NXT629 is a potent, selective, and competitive PPAR-α antagonist. It has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-09-28. Prices are subject to change without notice.

NXT629 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 462566
Name: NXT629
CAS#: 1454925-59-7
Chemical Formula: C35H39N5O3S
Exact Mass: 609.2774
Molecular Weight: 609.789
Elemental Analysis: C, 68.94; H, 6.45; N, 11.49; O, 7.87; S, 5.26

Synonym: NXT629; NXT-629; NXT 629

IUPAC/Chemical Name: N-(6-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenyl)pyridin-3-yl)benzenesulfonamide


InChi Code: InChI=1S/C35H39N5O3S/c1-5-39-33(37-40(34(39)41)25-27-16-20-29(21-17-27)35(2,3)4)13-9-10-26-14-18-28(19-15-26)32-23-22-30(24-36-32)38-44(42,43)31-11-7-6-8-12-31/h6-8,11-12,14-24,38H,5,9-10,13,25H2,1-4H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Bravo Y, Baccei CS, Broadhead A, et al. Identification of the first potent, selective and bioavailable PPARα antagonist. Bioorg Med Chem Lett. 2014;24(10):2267-2272. doi:10.1016/j.bmcl.2014.03.090

2: Stebbins KJ, Broadhead AR, Cabrera G, et al. In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist. Eur J Pharmacol. 2017;809:130-140. doi:10.1016/j.ejphar.2017.05.008