RBN-2397
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MedKoo CAT#: 462554

CAS#: 2381037-82-5

Description: Atamparib, also known as RBN-2397, is a potent, across species and orally active NAD+ competitive inhibitor of PARP7. RBN-2397 selectively binds to PARP7 and restores interferon (Type I) signaling. RBN-2397 has the potential for the study of advanced or metastatic solid tumors.

Chemical Structure

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RBN-2397
CAS# 2381037-82-5
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 462554
Name: RBN-2397
CAS#: 2381037-82-5
Chemical Formula: C20H23F6N7O3
Exact Mass: 523.18
Molecular Weight: 523.440
Elemental Analysis: C, 45.89; H, 4.43; F, 21.78; N, 18.73; O, 9.17

Price and Availability

Size Price Availability Quantity
1mg USD 90 Ready to ship
5mg USD 250 Ready to ship
10mg USD 450 Ready to ship
25mg USD 750 Ready to ship
50mg USD 1250 Ready to ship
100mg USD 1950 Ready to ship
200mg USD 2950 Ready to ship
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Synonym: Atamparib; RBN-2397; RBN 2397; RBN2397

IUPAC/Chemical Name: (S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one

InChi Key: UQZCQKXJAXKZQH-LBPRGKRZSA-N

InChi Code: InChI=1S/C20H23F6N7O3/c1-12(30-14-10-29-31-17(35)16(14)20(24,25)26)11-36-7-2-15(34)32-3-5-33(6-4-32)18-27-8-13(9-28-18)19(21,22)23/h8-10,12H,2-7,11H2,1H3,(H2,30,31,35)/t12-/m0/s1

SMILES Code: O=C1C(C(F)(F)F)=C(N[C@@H](C)COCCC(N2CCN(C3=NC=C(C(F)(F)F)C=N3)CC2)=O)C=NN1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: RBN-2397 is a potent NAD+ competitive inhibitor of PARP7 (IC50<3 nM) that selectively binds to PARP7 (Kd=0.001 μM) and restores IFN signaling.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 200.0 382.10

Preparing Stock Solutions

The following data is based on the product molecular weight 523.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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https://cancerres.aacrjournals.org/content/80/16_Supplement/DDT02-01