Vps34-IN-2
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462532

CAS#: 1523404-29-6

Description: Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34.

Chemical Structure

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Vps34-IN-2
CAS# 1523404-29-6
Instruction

Theoretical Analysis

MedKoo Cat#: 462532
Name: Vps34-IN-2
CAS#: 1523404-29-6
Chemical Formula: C18H25F3N4O3
Exact Mass: 402.19
Molecular Weight: 402.418
Elemental Analysis: C, 53.72; H, 6.26; F, 14.16; N, 13.92; O, 11.93

Price and Availability

Size Price Availability Quantity
1mg USD 410 2 Weeks
5mg USD 1000 2 Weeks
10mg USD 1510 2 Weeks
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Synonym: Vps34-IN-2; Vps34-IN 2; Vps34 IN-2; Vps34 IN 2

IUPAC/Chemical Name: (S)-9-(3-methyl-2-oxobutyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

InChi Key: ITCIAOUZMPREOO-OCCSQVGLSA-N

InChi Code: InChI=1S/C18H25F3N4O3/c1-11(2)13(26)9-25-14(18(19,20)21)4-5-24-16(27)8-15(22-17(24)25)23-6-7-28-10-12(23)3/h8,11-12,14H,4-7,9-10H2,1-3H3/t12-,14+/m1/s1

SMILES Code: O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC(C(C)C)=O)[C@H](C(F)(F)F)CCN31

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 402.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pasquier B, El-Ahmad Y, Filoche-Rommé B, et al. Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. J Med Chem. 2015;58(1):376-400. doi:10.1021/jm5013352