Nevirapine EP Impurity B

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MedKoo CAT#: 574591

CAS#: 287980-84-1

Description: Nevirapine EP Impurity B is a derivative of Nevirapine -- a potent and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-10-29. Prices are subject to change without notice.

Nevirapine EP Impurity B is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 574591
Name: Nevirapine EP Impurity B
CAS#: 287980-84-1
Chemical Formula: C12H10N4O
Exact Mass: 226.0855
Molecular Weight: 226.24
Elemental Analysis: C, 63.71; H, 4.46; N, 24.76; O, 7.07


Synonym: BIRG 616 BS; Nevirapine EP Impurity B

IUPAC/Chemical Name: 5,11-Dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

InChi Key: RKCRKBSFEVQVSX-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H10N4O/c1-7-4-6-14-11-9(7)15-12(17)8-3-2-5-13-10(8)16-11/h2-6H,1H3,(H,15,17)(H,13,14,16)

SMILES Code: O=C1C2=CC=CN=C2NC3=NC=CC(C)=C3N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1. Milinkovic A, Martínez E. Nevirapine in the treatment of HIV. Expert Rev Anti Infect Ther. 2004;2(3):367-373. doi:10.1586/14787210.2.3.367

2. Gopalan BP, Mehta K, D'souza RR, et al. Sub-therapeutic nevirapine concentration during antiretroviral treatment initiation among children living with HIV: Implications for therapeutic drug monitoring. PLoS One. 2017;12(8):e0183080. Published 2017 Aug 21. doi:10.1371/journal.pone.0183080