WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462514

CAS#: 1681017-83-3 (free base)

Description: Venadaparib, also known as IDX-1197, is a potent, selective and orally active PARP inhibitor with IC50s of 1 ~2 nM.. By inhibiting PARP, IDX-1197 stops cancer cells from repairing SSBs and drives the conversion of SSBs into double-strand breaks. IDX-1197 triggers a phenomenon known as synthetic lethality, which is defined by cell death resulting from the simultaneous perturbation of two genes without damaging normal cells. IDX-1197 is primarily aimed at treating homologous recombination deficient (HRD) patients. Notably, IDX-1197 has a particularly strong trapping effect, meaning it is more effective at trapping PARP1 and PARP2 enzymes on damaged DNA.

Chemical Structure

CAS# 1681017-83-3 (free base)

Theoretical Analysis

MedKoo Cat#: 462514
Name: Venadaparib
CAS#: 1681017-83-3 (free base)
Chemical Formula: C23H23FN4O2
Exact Mass: 406.18
Molecular Weight: 406.461
Elemental Analysis: C, 67.97; H, 5.70; F, 4.67; N, 13.78; O, 7.87

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
50mg USD 750 2 Weeks
100mg USD 1250 2 Weeks
200mg USD 1950 2 Weeks
500mg USD 3650 2 Weeks
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Related CAS #: 1681020-60-9 (HCl)   1681017-83-3 (free base)  

Synonym: Venadaparib; IDX-1197; IDX 1197; IDX1197;

IUPAC/Chemical Name: 34-fluoro-7-aza-1(1)-phthalazina-5(1,3)-azetidina-3(1,3)-benzena-8(1)-cyclopropanaoctaphane-14(13H),4-dione


InChi Code: InChI=1S/C23H23FN4O2/c24-20-8-5-14(10-21-17-3-1-2-4-18(17)22(29)27-26-21)9-19(20)23(30)28-12-15(13-28)11-25-16-6-7-16/h1-5,8-9,15-16,25H,6-7,10-13H2,(H,27,29)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 406.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: WHO Drug Information, Vol. 34, No. 2, 2020