K00546
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MedKoo CAT#: 462496

CAS#: 443798-47-8

Description: K00546 is a potent CDK1 and CDK2 inhibitor and is a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor


Chemical Structure

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K00546
CAS# 443798-47-8

Theoretical Analysis

MedKoo Cat#: 462496
Name: K00546
CAS#: 443798-47-8
Chemical Formula: C15H13F2N7O2S2
Exact Mass: 425.054
Molecular Weight: 425.4328
Elemental Analysis: C, 42.35; H, 3.08; F, 8.93; N, 23.05; O, 7.52; S, 15.07

Price and Availability

Size Price Availability Quantity
5.0mg USD 460.0 2 Weeks
10.0mg USD 740.0 2 Weeks
50.0mg USD 1750.0 2 Weeks
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Synonym: K00546; K 00546; K-00546

IUPAC/Chemical Name: 5-amino-N-(2,6-difluorophenyl)-3-((4-sulfamoylphenyl)amino)-1H-1,2,4-triazole-1-carbothioamide

InChi Key: ARIOBGGRZJITQX-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)

SMILES Code: S=C(N1N=C(NC2=CC=C(S(=O)(N)=O)C=C2)N=C1N)NC3=C(F)C=CC=C3F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 425.4328 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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Dilution Calculator

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1: Pike AC, Rellos P, Niesen FH, et al. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J. 2008;27(4):704-714. doi:10.1038/emboj.2008.8

2: Fedorov O, Huber K, Eisenreich A, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011;18(1):67-76. doi:10.1016/j.chembiol.2010.11.009

K00546

5.0mg / USD 460.0