WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462460
CAS#: 2366264-12-0
Description: MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3. It is not toxic to nontumorigenic cells.
MedKoo Cat#: 462460
Name: MS31
CAS#: 2366264-12-0
Chemical Formula: C20H27N3O2
Exact Mass: 341.2103
Molecular Weight: 341.455
Elemental Analysis: C, 70.35; H, 7.97; N, 12.31; O, 9.37
Synonym: MS 31; MS-31; MS31
IUPAC/Chemical Name: (5-(3-(isoindolin-2-yl)propoxy)-4-methoxy-1,3-phenylene)dimethanamine
InChi Key: XQQZNYFJATXWON-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H27N3O2/c1-24-20-18(12-22)9-15(11-21)10-19(20)25-8-4-7-23-13-16-5-2-3-6-17(16)14-23/h2-3,5-6,9-10H,4,7-8,11-14,21-22H2,1H3
SMILES Code: NCC1=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=CC(CN)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 341.455 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Xiong Y, Greschik H, Johansson C, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). J Med Chem. 2019;62(20):8996-9007. doi:10.1021/acs.jmedchem.9b00522
