WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574528
CAS#: 84211-05-2 (sodium)
Description: Mafosfamide is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis.
MedKoo Cat#: 574528
Name: Mafosfamide sodium
CAS#: 84211-05-2 (sodium)
Chemical Formula: C9H18Cl2N2NaO5PS2
Molecular Weight: 423.24
Elemental Analysis: C, 25.54; H, 4.29; Cl, 16.75; N, 6.62; Na, 5.43; O, 18.90; P, 7.32; S, 15.15
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 88859-04-5 (free acid) 84211-05-2 (sodium) 84210-80-0 (CHA salt) 98845-64-8 (lysine)
Synonym: Mafosfamide Sodium Salt, Mafosfamid Sodium; Z 7557; cis-Mafosfamide Sodium
IUPAC/Chemical Name: sodium 2-(((4R)-2-(bis(2-chloroethyl)amino)-2-oxido-1,3,2-oxazaphosphinan-4-yl)thio)ethane-1-sulfonate
InChi Key: LHXWPBHSZFEANP-IBEXIAAFSA-M
InChi Code: InChI=1S/C9H19Cl2N2O5PS2.Na/c10-2-4-13(5-3-11)19(14)12-9(1-6-18-19)20-7-8-21(15,16)17;/h9H,1-8H2,(H,12,14)(H,15,16,17);/q;+1/p-1/t9-,19?;/m1./s1
SMILES Code: ClCCN(P1(OCC[C@@H](SCCS(=O)([O-])=O)N1)=O)CCCl.[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 423.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|