WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462448
Description: 2'-Deoxyguanosine is a purine nucleoside with diverse biological activities. It inhibits the clonogenic growth of HL-60 and K562 leukemia cells.
MedKoo Cat#: 462448
Chemical Formula: C10H13N5O4
Exact Mass: 267.0968
Molecular Weight: 267.245
Elemental Analysis: C, 44.94; H, 4.90; N, 26.21; O, 23.95
Synonym: 2'-Deoxyguanosine; Guanine deoxyriboside; NSC 22837; NSC-22837; NSC-22837
IUPAC/Chemical Name: 2-amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one
InChi Key: YKBGVTZYEHREMT-KVQBGUIXSA-N
InChi Code: InChI=1S/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1
SMILES Code: NC1=NC(C(N=CN2[C@]3([H])O[C@H](CO)[C@@H](O)C3)=C2N1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 267.245 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ross, D.D., Akman, S.A., Schrecker, A.W., et al. Effects of deoxynucleosides on cultured human leukemia cell growth and deoxynucleotide pools. Cancer Res. 41(11 Pt 1), 4493-4498 (1981).
2: Mitchell, B.S., Mejias, E., Daddona, P.E., et al. Purinogenic immunodeficiency diseases: Selective toxicity of deoxyribonucleosides for T cells. Proc. Natl. Acad. Sci. USA 75(10), 5011-5014 (1978).
3: Brulfert, A., Clain, E., and Deysson, G. Deoxyguanosine, a potent cytokinesis inhibitor in plant cells. Experientia 30(9), 1010-1011 (1974).
4: Scholar, E.M. Effect of deoxypurine and deoxypyrimidine compounds on the vascular responsiveness of bovine coronary and lingual arteries. J. Pharm. Pharmacol. 32(10), 726 (1980).