UC-514321
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462440

CAS#: 299420-83-0

Description: UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 435 2 Weeks
10mg USD 745 2 Weeks
50mg USD 1845 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-29. Prices are subject to change without notice.

UC-514321 is in stock.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 462440
Name: UC-514321
CAS#: 299420-83-0
Chemical Formula: C26H35NO5
Exact Mass: 441.2515
Molecular Weight: 441.568
Elemental Analysis: C, 70.72; H, 7.99; N, 3.17; O, 18.12


Synonym: UC-514321; UC514321; UC 514321

IUPAC/Chemical Name: 6-((3,5-di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol

InChi Key: XNARHFDDQALZPZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H35NO5/c1-25(2,3)18-11-16(12-19(24(18)29)26(4,5)6)23(27-7-9-30-10-8-27)17-13-21-22(14-20(17)28)32-15-31-21/h11-14,23,28-29H,7-10,15H2,1-6H3

SMILES Code: OC1=C(C(C)(C)C)C=C(C(C2=C(O)C=C(OCO3)C3=C2)N4CCOCC4)C=C1C(C)(C)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Jiang X, Hu C, Ferchen K, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia [published correction appears in Nat Commun. 2018 Feb 9;9(1):670]. Nat Commun. 2017;8(1):2099. Published 2017 Dec 13. doi:10.1038/s41467-017-02290-w