WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462428

CAS#: 2031177-48-5

Description: ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor that is orally active.

Chemical Structure

CAS# 2031177-48-5

Theoretical Analysis

MedKoo Cat#: 462428
Name: ZM223
CAS#: 2031177-48-5
Chemical Formula: C23H17F3N4O2S2
Exact Mass: 502.0745
Molecular Weight: 502.5302
Elemental Analysis: C, 54.97; H, 3.41; F, 11.34; N, 11.15; O, 6.37; S, 12.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ZM223; ZM 223; ZM-223

IUPAC/Chemical Name: N-(6-(2-((4-aminophenyl)thio)acetamido)benzo[d]thiazol-2-yl)-4-(trifluoromethyl)benzamide


InChi Code: InChI=1S/C23H17F3N4O2S2/c24-23(25,26)14-3-1-13(2-4-14)21(32)30-22-29-18-10-7-16(11-19(18)34-22)28-20(31)12-33-17-8-5-15(27)6-9-17/h1-11H,12,27H2,(H,28,31)(H,29,30,32)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 502.5302 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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1: Ma H, Zhuang C, Xu X, et al. Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening. Eur J Med Chem. 2017;133:174-183. doi:10.1016/j.ejmech.2017.03.076