AMG 925 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462410

CAS#: 1401034-19-2

Description: AMG 925 HCl is a potent, selective, and orally available FLT3/CDK4 dual inhibitor.

Chemical Structure

AMG 925 HCl
CAS# 1401034-19-2

Theoretical Analysis

MedKoo Cat#: 462410
Name: AMG 925 HCl
CAS#: 1401034-19-2
Chemical Formula: C26H30ClN7O2
Exact Mass: 507.215
Molecular Weight: 508.023
Elemental Analysis: C, 61.47; H, 5.95; Cl, 6.98; N, 19.30; O, 6.30

Price and Availability

Size Price Availability Quantity
5.0mg USD 265.0 2 Weeks
10.0mg USD 410.0 2 Weeks
100.0mg USD 1000.0 2 Weeks
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Synonym: AMG 925 HCl; AMG925 HCl; AMG-925 HCl

IUPAC/Chemical Name: 2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethan-1-one hydrochloride


InChi Code: InChI=1S/C26H29N7O2.ClH/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23;/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31);1H/t16-,18-;

SMILES Code: OCC(N1CC2=C(N=C(NC3=NC=C4C(N([C@H]5CC[C@H](C)CC5)C6=CN=CC=C64)=N3)C=C2)CC1)=O.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 508.023 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Keegan K, Li C, Li Z, et al. Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. Mol Cancer Ther. 2014;13(4):880-889. doi:10.1158/1535-7163.MCT-13-0858