CCI-006
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462390

CAS#: 292053-42-0

Description: CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibiting mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells.

Chemical Structure

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CCI-006
CAS# 292053-42-0
Instruction

Theoretical Analysis

MedKoo Cat#: 462390
Name: CCI-006
CAS#: 292053-42-0
Chemical Formula: C15H12N2O5S
Exact Mass: 0.00
Molecular Weight: 332.330
Elemental Analysis: C, 54.21; H, 3.64; N, 8.43; O, 24.07; S, 9.65

Price and Availability

Size Price Availability Quantity
5mg USD 530 2 Weeks
10mg USD 840 2 Weeks
50mg USD 2100 2 Weeks
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Synonym: CCI-006; CCI-006; CCI-006

IUPAC/Chemical Name: methyl (E)-2-cyano-3-(5-(4-sulfamoylphenyl)furan-2-yl)acrylate

InChi Key: VEXAKEBSBMAIOB-DHZHZOJOSA-N

InChi Code: InChI=1S/C15H12N2O5S/c1-21-15(18)11(9-16)8-12-4-7-14(22-12)10-2-5-13(6-3-10)23(17,19)20/h2-8H,1H3,(H2,17,19,20)/b11-8+

SMILES Code: O=C(/C(C#N)=C/C1=CC=C(C2=CC=C(S(=O)(N)=O)C=C2)O1)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 332.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Somers K, Wen VW, Middlemiss SMC, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019;38(20):3824-3842. doi:10.1038/s41388-018-0666-5