WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462372

CAS#: 885898-58-8

Description: VA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy

Chemical Structure

CAS# 885898-58-8

Theoretical Analysis

MedKoo Cat#: 462372
Name: VA012
CAS#: 885898-58-8
Chemical Formula: C21H19N3
Exact Mass: 313.1579
Molecular Weight: 313.404
Elemental Analysis: C, 80.48; H, 6.11; N, 13.41

Price and Availability

Size Price Availability Quantity
10.0mg USD 350.0 2 Weeks
50.0mg USD 950.0 2 Weeks
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Synonym: VA012; VA-012; VA 012

IUPAC/Chemical Name: N-((1-benzyl-1H-indol-3-yl)methyl)pyridin-3-amine


InChi Code: InChI=1S/C21H19N3/c1-2-7-17(8-3-1)15-24-16-18(20-10-4-5-11-21(20)24)13-23-19-9-6-12-22-14-19/h1-12,14,16,23H,13,15H2


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 313.404 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wold, Eric A et al. “Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.” Journal of medicinal chemistry vol. 62,1 (2019): 88-127. doi:10.1021/acs.jmedchem.8b00875

2: Wold, Eric A et al. “Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development.” Current topics in medicinal chemistry vol. 19,16 (2019): 1381-1398. doi:10.2174/1568026619666190709101449


10.0mg / USD 350.0