WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462372
CAS#: 885898-58-8
Description: VA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy
MedKoo Cat#: 462372
Name: VA012
CAS#: 885898-58-8
Chemical Formula: C21H19N3
Exact Mass: 313.1579
Molecular Weight: 313.404
Elemental Analysis: C, 80.48; H, 6.11; N, 13.41
Synonym: VA012; VA-012; VA 012
IUPAC/Chemical Name: N-((1-benzyl-1H-indol-3-yl)methyl)pyridin-3-amine
InChi Key: FXRHZHGEENHPFI-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H19N3/c1-2-7-17(8-3-1)15-24-16-18(20-10-4-5-11-21(20)24)13-23-19-9-6-12-22-14-19/h1-12,14,16,23H,13,15H2
SMILES Code: C1=CC=C(NCC2=CN(CC3=CC=CC=C3)C3=CC=CC=C23)C=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 313.404 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Wold, Eric A et al. “Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.” Journal of medicinal chemistry vol. 62,1 (2019): 88-127. doi:10.1021/acs.jmedchem.8b00875
2: Wold, Eric A et al. “Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development.” Current topics in medicinal chemistry vol. 19,16 (2019): 1381-1398. doi:10.2174/1568026619666190709101449
