WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462362

CAS#: 306959-01-3

Description: MYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor with anti-angiogenesis and anti-cancer activity. MYLS22 inhibits angiogenesis and tumor growth and metastatization, by impinging on NFkB activity and on angiogenic gene expression. In addition, MYLS22 causes tumor growth curtailed mice with 10 mg/kg/die.

Chemical Structure

CAS# 306959-01-3

Theoretical Analysis

MedKoo Cat#: 462362
Name: MYLS22
CAS#: 306959-01-3
Chemical Formula: C24H21N5O2S
Exact Mass: 443.1416
Molecular Weight: 443.525
Elemental Analysis: C, 64.99; H, 4.77; N, 15.79; O, 7.21; S, 7.23

Price and Availability

Size Price Availability Quantity
5.0mg USD 250.0 2 Weeks
10.0mg USD 450.0 2 Weeks
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Synonym: MYLS22; MYLS-22; MYLS 22

IUPAC/Chemical Name: N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide


InChi Code: InChI=1S/C24H21N5O2S/c1-15-19-14-20(32-24(19)28(26-15)17-10-6-4-7-11-17)22(30)25-21-16(2)27(3)29(23(21)31)18-12-8-5-9-13-18/h4-14H,1-3H3,(H,25,30)

SMILES Code: O=C(C(S1)=CC2=C1N(C3=CC=CC=C3)N=C2C)NC4=C(C)N(C)N(C5=CC=CC=C5)C4=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 443.525 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Herkenne S, Ek O, Zamberlan M, et al. Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. Cell Metab. 2020;31(5):987-1003.e8. doi:10.1016/j.cmet.2020.04.007


5.0mg / USD 250.0