WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 535045
CAS#: 254750-11-3
Description: IDN-7314 is a bioactive chemical.
MedKoo Cat#: 535045
Name: IDN-7314
CAS#: 254750-11-3
Chemical Formula: C22H16F6N2O7
Exact Mass: 534.0862
Molecular Weight: 534.3674
Elemental Analysis: C, 49.45; H, 3.02; F, 21.33; N, 5.24; O, 20.96
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: IDN-7314; IDN 7314; IDN7314
IUPAC/Chemical Name: N-(2,6-Difluorophenyl)-2-oxoglycyl-N-((1S)-1-(carboxymethyl)-2-oxo-3- (2,3,5,6-tetrafluorophenoxy)propyl)-L-alaninamide
InChi Key: FEWNIOCTWJRBDB-XPTSAGLGSA-N
InChi Code: InChI=1S/C22H16F6N2O7/c1-9(22(36)29-16(33)7-31)30(20-10(23)3-2-4-11(20)24)14(6-17(34)35)15(32)8-37-21-18(27)12(25)5-13(26)19(21)28/h2-5,7,9,14H,6,8H2,1H3,(H,34,35)(H,29,33,36)/t9-,14-/m0/s1
SMILES Code: C[C@@H](C(NC(C=O)=O)=O)N(C1=C(F)C=CC=C1F)[C@@H](CC(O)=O)C(COC2=C(F)C(F)=CC(F)=C2F)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 534.3674 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Liao L, Schneider KM, Galvez EJC, Frissen M, Marschall HU, Su H, Hatting M, Wahlström A, Haybaeck J, Puchas P, Mohs A, Peng J, Bergheim I, Nier A, Hennings J, Reißing J, Zimmermann HW, Longerich T, Strowig T, Liedtke C, Cubero FJ, Trautwein C. Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis. Gut. 2019 Aug;68(8):1477-1492. doi: 10.1136/gutjnl-2018-316670. Epub 2019 Mar 14. PMID: 30872395.
2: Kopec AK, Spada AP, Contreras PC, Mackman N, Luyendyk JP. Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo. Toxicol Sci. 2018 Apr 1;162(2):396-405. doi: 10.1093/toxsci/kfx268. PMID: 29228388; PMCID: PMC5888917.
3: Copple BL, Rondelli CM, Maddox JF, Hoglen NC, Ganey PE, Roth RA. Modes of cell death in rat liver after monocrotaline exposure. Toxicol Sci. 2004 Jan;77(1):172-82. doi: 10.1093/toxsci/kfh011. Epub 2003 Nov 4. PMID: 14600277.
4: Cubero FJ, Peng J, Liao L, Su H, Zhao G, Zoubek ME, Macías-Rodríguez R, Ruiz- Margain A, Reißing J, Zimmermann HW, Gassler N, Luedde T, Liedtke C, Hatting M, Trautwein C. Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis. J Hepatol. 2018 Dec;69(6):1326-1334. doi: 10.1016/j.jhep.2018.08.015. Epub 2018 Aug 23. PMID: 30144553.
5: Oliver Metzig M, Fuchs D, Tagscherer KE, Gröne HJ, Schirmacher P, Roth W. Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF- α-dependent necroptosis driven by RIP1 kinase and NF-κB. Oncogene. 2016 Jun 30;35(26):3399-409. doi: 10.1038/onc.2015.398. Epub 2015 Nov 2. PMID: 26522725.
6: Gujral JS, Farhood A, Jaeschke H. Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats. Toxicol Appl Pharmacol. 2003 Jul 1;190(1):37-46. doi: 10.1016/s0041-008x(03)00154-6. PMID: 12831781.
