IDN-7314

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 535045

CAS#: 254750-11-3

Description: IDN-7314 is a bioactive chemical.


Chemical Structure

img
IDN-7314
CAS# 254750-11-3

Theoretical Analysis

MedKoo Cat#: 535045
Name: IDN-7314
CAS#: 254750-11-3
Chemical Formula: C22H16F6N2O7
Exact Mass: 534.0862
Molecular Weight: 534.3674
Elemental Analysis: C, 49.45; H, 3.02; F, 21.33; N, 5.24; O, 20.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: IDN-7314; IDN 7314; IDN7314

IUPAC/Chemical Name: N-(2,6-Difluorophenyl)-2-oxoglycyl-N-((1S)-1-(carboxymethyl)-2-oxo-3- (2,3,5,6-tetrafluorophenoxy)propyl)-L-alaninamide

InChi Key: FEWNIOCTWJRBDB-XPTSAGLGSA-N

InChi Code: InChI=1S/C22H16F6N2O7/c1-9(22(36)29-16(33)7-31)30(20-10(23)3-2-4-11(20)24)14(6-17(34)35)15(32)8-37-21-18(27)12(25)5-13(26)19(21)28/h2-5,7,9,14H,6,8H2,1H3,(H,34,35)(H,29,33,36)/t9-,14-/m0/s1

SMILES Code: C[C@@H](C(NC(C=O)=O)=O)N(C1=C(F)C=CC=C1F)[C@@H](CC(O)=O)C(COC2=C(F)C(F)=CC(F)=C2F)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 534.3674 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Liao L, Schneider KM, Galvez EJC, Frissen M, Marschall HU, Su H, Hatting M, Wahlström A, Haybaeck J, Puchas P, Mohs A, Peng J, Bergheim I, Nier A, Hennings J, Reißing J, Zimmermann HW, Longerich T, Strowig T, Liedtke C, Cubero FJ, Trautwein C. Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis. Gut. 2019 Aug;68(8):1477-1492. doi: 10.1136/gutjnl-2018-316670. Epub 2019 Mar 14. PMID: 30872395.

2: Kopec AK, Spada AP, Contreras PC, Mackman N, Luyendyk JP. Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo. Toxicol Sci. 2018 Apr 1;162(2):396-405. doi: 10.1093/toxsci/kfx268. PMID: 29228388; PMCID: PMC5888917.

3: Copple BL, Rondelli CM, Maddox JF, Hoglen NC, Ganey PE, Roth RA. Modes of cell death in rat liver after monocrotaline exposure. Toxicol Sci. 2004 Jan;77(1):172-82. doi: 10.1093/toxsci/kfh011. Epub 2003 Nov 4. PMID: 14600277.

4: Cubero FJ, Peng J, Liao L, Su H, Zhao G, Zoubek ME, Macías-Rodríguez R, Ruiz- Margain A, Reißing J, Zimmermann HW, Gassler N, Luedde T, Liedtke C, Hatting M, Trautwein C. Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis. J Hepatol. 2018 Dec;69(6):1326-1334. doi: 10.1016/j.jhep.2018.08.015. Epub 2018 Aug 23. PMID: 30144553.

5: Oliver Metzig M, Fuchs D, Tagscherer KE, Gröne HJ, Schirmacher P, Roth W. Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF- α-dependent necroptosis driven by RIP1 kinase and NF-κB. Oncogene. 2016 Jun 30;35(26):3399-409. doi: 10.1038/onc.2015.398. Epub 2015 Nov 2. PMID: 26522725.

6: Gujral JS, Farhood A, Jaeschke H. Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats. Toxicol Appl Pharmacol. 2003 Jul 1;190(1):37-46. doi: 10.1016/s0041-008x(03)00154-6. PMID: 12831781.