WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462342
Description: 6RK73 is a covalent irreversible and specific UCHL1 inhibitor. It specifically inhibits UCHL1 activity in breast cancer.
MedKoo Cat#: 462342
Chemical Formula: C13H17N5O2S
Exact Mass: 307.1103
Molecular Weight: 307.372
Elemental Analysis: C, 50.80; H, 5.58; N, 22.79; O, 10.41; S, 10.43
Synonym: 6RK73; 6 RK73; 6-RK73
IUPAC/Chemical Name: (S)-1-cyano-N-(5-morpholinothiazol-2-yl)pyrrolidine-3-carboxamide
InChi Key: ONIHSXKWNFYNNS-JTQLQIEISA-N
InChi Code: InChI=1S/C13H17N5O2S/c14-9-17-2-1-10(8-17)12(19)16-13-15-7-11(21-13)18-3-5-20-6-4-18/h7,10H,1-6,8H2,(H,15,16,19)/t10-/m0/s1
SMILES Code: O=C([C@@H]1CN(C#N)CC1)NC2=NC=C(N3CCOCC3)S2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 307.372 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Liu S, González-Prieto R, Zhang M, et al. Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis. Clin Cancer Res. 2020;26(6):1460-1473. doi:10.1158/1078-0432.CCR-19-1373